Publications by authors named "Nobuyo Oya"
Article Synopsis
- This study aimed to compare the effectiveness, safety, and pharmacokinetics of remifentanil versus fentanyl for pain management in mechanically ventilated ICU patients.
- A total of 196 patients were randomly assigned to receive either remifentanil or fentanyl, with both groups achieving high rates of effective pain relief and no significant difference in adverse events between the medications.
- The study confirmed that remifentanil was non-inferior to fentanyl in managing pain, and showed that it had a rapid decline in blood concentration after administration ceased, indicating quick recovery from its effects.
Importance: Patients with pruritus receiving hemodialysis frequently experience oppressive physical and psychiatric symptoms that directly affect their quality of life and increase mortality. However, treatment options are limited.
Objective: To determine the clinically recommended dose of difelikefalin, a κ-opioid receptor agonist, based on the efficacy, dose response, safety, and pharmacokinetics.
Background: Few studies (in other countries than the US) have reported on the efficacy and safety of dexmedetomidine for sedation of patients undergoing surgical or medical procedures under local anesthesia without intubation outside the intensive care unit. We performed a randomized, double-blind study in Japan.
Methods: Adult patients were randomly allocated to receive placebo, dexmedetomidine 0.
Background: Only a few studies have been reported on the use of dexmedetomidine for sedating surgical patients requiring epidural or spinal anesthesia. We conducted a randomized, double-blind, placebo-controlled, parallel-group study at 12 hospitals in Japan.
Methods: Adult patients were randomly allocated to receive an intravenous administration of placebo or dexmedetomidine at 0.