Publications by authors named "Nobutaka Hayashi"
Article Synopsis
- A study conducted in Japan examined the use of comprehensive genomic profiling (CGP) in patients with gynecological cancers, involving nine cancer hospitals and a total of 450 patients.
- The CGP group had fewer cases of cervical cancer and included younger patients compared to the control group, with significant differences in median ages (54 vs. 65 years).
- Although only 12.7% of CGP patients received recommended treatments (mostly not covered by insurance), those who did experienced improved survival rates (median 21 months) compared to others in the CGP group (median 11 months).
Article Synopsis
- The patient, a woman in her 70s, had a history of bladder cancer and developed a ureterocutaneous fistula after a cystectomy.
- A colonoscopy revealed a type 1 elevated lesion in the ascending colon, diagnosed as well-differentiated adenocarcinoma, prompting surgical intervention.
- The surgery was carefully performed to avoid complications with the ureter, lasting 246 minutes with minimal blood loss, and the patient was discharged on the 6th day post-op, currently in recurrence-free follow-up.
Article Synopsis
- - A 70-year-old woman with locally advanced rectal cancer, initially deemed inoperable due to tumor invasion, presented with abdominal pain and was later diagnosed with the condition.
- - She received 11 courses of chemotherapy using mFOLFOX6 and cetuximab, which resulted in significant tumor shrinkage.
- - Following the positive response to chemotherapy, she underwent successful robotic-assisted laparoscopic surgery and remained relapse-free for 12 months post-operation, despite not receiving additional chemotherapy.
The patient is a 50s year old man. He visited his local doctor with complaints of anal pain and bloody stools, and a rectal examination revealed a tumor on the anterior wall of the rectal canal. CT imaging showed tumors invading the prostate, urethra, and anorectal muscles, and a 3 mm-sized nodule was found in the lungs.
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- Acute pulmonary edema can occur as a rare but serious side effect of ritodrine hydrochloride, especially with longer doses.
- A case study describes a 30-year-old pregnant woman who experienced this complication after a short infusion of ritodrine during labor, alongside existing conditions like pectus excavatum.
- Postoperative pulmonary edema was successfully treated with supportive care, highlighting the need for caution when using ritodrine in patients with specific medical issues.
An 80-year-old woman presented with sudden-onset dysarthria and left-side dominant quadriparesis and transferred to our hospital. A neurologic examination revealed slurred speech, prominent left upper extremity weakness and mild weakness of the other extremities. Brain MRI revealed a history of right-side cerebral artery bypass surgery, but no new lesions indicative of stroke.
View Article and Find Full Text PDFIntroduction New-onset systemic lupus erythematosus (SLE) during pregnancy is rare and difficult to diagnose, especially in cases that manifest as preeclampsia. We report a patient with new-onset SLE that manifested as preeclampsia during pregnancy and provide a review of the literature to identify factors for a rapid diagnosis. Case A 32-year-old primigravid Japanese woman was diagnosed with severe preeclampsia and underwent emergent cesarean section at 29 weeks of gestation.
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- The study investigates how the Foxo3 transcription factor affects lifespan extension and cancer suppression in mice under dietary restriction (DR).
- Researchers compared wild-type (WT) mice to Foxo3-knockout mice (heterozygous and homozygous) subjected to a 30% DR at 12 weeks old.
- Results show that while DR significantly extends lifespan in WT mice, it doesn’t have the same effect on Foxo3-knockout mice, indicating Foxo3 is essential for longevity but not for reducing cancer prevalence under DR.
The aim of this study was to elucidate the mechanism by which curing agents, especially nitrite, inhibit the formation of zinc protoporphyrin IX (ZPP) in dry-cured hams such as Parma ham. The oxidation-reduction potential of model solutions was increased by the addition of nitrite, but it was not clear whether the formation of ZPP is inhibited by the oxidizing property of nitrite. The effect of nitric oxide (NO) produced from nitrite on the formation of ZPP was examined.
View Article and Find Full Text PDFZinc protoporphyrin IX (ZPP) is a characteristic red pigment in meat products that are manufactured without the addition of a curing agent such as nitrate or nitrite. To examine the effects of impurities such as mineral components in sea salt on the formation of ZPP, we manufactured Parmatype dry-cured hams that were salted with refined salt or sea salt and examined the involvement of oxidation-reduction potential (ORP) in the formation of ZPP. The content of ZPP was increased drastically after 40 weeks.
View Article and Find Full Text PDFWe examined the effects of exogenous myoglobin, a bivalent chelator, and nitrite on Zn protoporphyrin IX (ZPP) formation by using model systems. ZPP was formed in a model solution without addition of exogenous myoglobin. After incubation, the amount of ZPP in a model solution was increased but that of heme was not decreased compared with the amounts before incubation.
View Article and Find Full Text PDFTransferable resistance to various drugs was investigated in Photobacterium damselae subsp. piscicida from Japan. Drug resistances were transferred via plasmids of 100, 50, and 40 kb.
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