Publications by authors named "Nobuo Takemori"

Article Synopsis
  • Clarithromycin (CAM) is a semisynthetic antibiotic that has shown potential as an add-on therapy for multiple myeloma (MM), though it is not effective as a standalone treatment.
  • Its effectiveness in MM treatment may be due to its ability to suppress myeloma growth factors like interleukin-6 and modulate immune responses among other mechanisms.
  • CAM's diverse effects could also extend to treating other conditions, like COVID-19, particularly through its impact on cytokines and possible antiviral properties.
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Background: In general, dexamethasone is a required component drug in various combination chemotherapies for treating multiple myeloma, and its efficacy has been widely recognized. However, administration of dexamethasone is known to cause various adverse effects including hyperglycemia which requires insulin therapy. During the course of treatment, we developed a novel effective dexamethasone-free combination regimen and evaluated it for its effect in multiple myeloma.

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Introduction: Sarcoidosis is recognized as a multiorgan disorder characterized by the presence of non-caseating granulomas in the involved tissues. It has been suggested that sarcoidosis might be due to the exposure to infectious or non-infectious agents in genetically susceptible individuals. In particular, Propionibacterium acnes and Mycobacterium tuberculosis have been considered causative microorganisms.

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Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin's lymphoma (HL), in which a dramatic complete remission was achieved after withdrawal of MTX coupled with clarithromycin (CAM) administration. Withdrawal of MTX coupled with CAM administration seemed to be effective for treating MTX-related EBV-associated LPDs.

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