Publications by authors named "Nobunori Takahashi"
Aim: The objective of this study was to compare the clinical effectiveness of baricitinib and abatacept in patients with rheumatoid arthritis (RA).
Methods: This study included 274 patients treated with abatacept and 241 treated with baricitinib who were followed for >52 weeks. Potential treatment selection bias was addressed by using inverse probability of treatment weighting.
Article Synopsis
- Malunion of thumb and finger fractures leads to issues with hand appearance and function, often resulting in rotational deformities in multiple planes.
- Corrective osteotomy is necessary for addressing these deformities, but accurately measuring the extent of the malunion, especially in the transverse plane, is challenging.
- A new technique called linkage simulation has been developed to quantify rotational deformities, allowing for better surgical planning and enabling simulations of finger movements and potential outcomes post-surgery.
Surgical treatment of fragility fractures of the pelvis: short-term outcomes of 42 patients.
Eur J Orthop Surg Traumatol
August 2024
Purpose: The present retrospective study aimed to analyze patient characteristics, perioperative complications, and short-term outcomes of surgery for fragility fractures of the pelvis (FFP).
Methods: We selected 42 patients who underwent surgery for FFP between October 2019 and October 2022 and could be followed for more than 6 months postoperatively, including one male patient and 41 female patients with an average age of 83.5 (65-96) years.
Objective: To assess safety of baricitinib in Japanese patients with rheumatoid arthritis in real-world clinical practice.
Methods: This all-case post-marketing surveillance study included patients initiating baricitinib for rheumatoid arthritis from September 2017 to April 2019. Treatment duration was recorded.
Objectives: The present study aimed to examine discrepancies between assessments based on Routine Assessment of Patient Index Data 3 (RAPID3) and Simple Disease Activity Index (SDAI) in RA patients with controlled disease activity.
Methods: Data from 464 RA patients in SDAI remission or low disease activity (REM/LDA) were analyzed. Patient-reported outcome (PRO) measures, including Health Assessment Questionnaire Disability Index (HAQ-DI), 25-question Geriatric Locomotive Function Scale (GLFS-25), and Kihon checklist (KCL), were assessed.
Background: This study aimed to investigate factors associated with frailty in rheumatoid arthritis (RA) patients.
Methods: A total of 656 RA patients were evaluated using data from an observational study in 2022. Among these patients, 152 with frailty were assigned to the frailty group, and 504 without frailty were assigned to the non-frailty group.
Objectives: To investigate a plateau in treatment enhancement for improving the frailty status of rheumatoid arthritis (RA) patients.
Methods: A total of 345 RA patients who were not robust in 2021 were assigned to the improved ("robust 2022," n = 51) and non-improved ("pre-frailty/frailty 2022," n = 294) groups. Factors associated with "robust 2022" were examined by logistic regression analysis.
Background: This study aimed to investigate the location and distribution of pain in adults with chronic low back pain (LBP) with degenerative lumbar scoliosis (DLS) according to coronal deformities.
Methods: We enrolled 100 adults with chronic LBP and DLS, dividing them into two groups, a right-convex DLS group (n = 50) and a left-convex DLS group (n = 50). Dominant pain location was analyzed by dividing it into three parts-left side, right side, and center-and pain areas were identified using the pain drawing method; then, a heat map was created for each group.
As bone and joint infections (BJIs) require long-term treatment, identifying their causative pathogens is vital. However, the detection rate of conventional culturing remains inadequate. This study aimed to evaluate the usefulness of the FilmArray blood culture identification (BCID) panel for identifying causative pathogens in patients with BJIs.
View Article and Find Full Text PDFObjective: Various guidelines recommend that patients with early rheumatoid arthritis (RA) try to achieve clinical remission within 6 months, and early therapeutic intervention is important to this end. This study aimed to investigate short-term treatment outcomes of patients with early-diagnosed RA in clinical practice and to examine predictive factors for achieving remission.
Methods: Of the 210 patients enrolled in the multicenter RA inception cohort, 172 patients who were followed up to 6 months after treatment initiation (baseline) were included.
Currently, there is no surgical assistance system that can perform a three-dimensional (3D) planned total hip arthroplasty (THA) by methods other than surgical assistance navigation or robots. However, they are expensive, cumbersome, and subject to additional invasiveness, so there is a need for a simpler and less expensive 3D surgical support system. In this study, THA was performed using the anterolateral approach (Watson-Jones) in the supine position in 23 subjects to examine the efficacy and safety of a patient-specific femoral guide linked to 3D surgery support software.
View Article and Find Full Text PDFArticle Synopsis
- * A case study of a 78-year-old woman illustrated the use of massive allografts in revision TEA after she experienced a periprosthetic humeral fracture following her initial surgery.
- * The innovative approach of preserving part of the thin humeral diaphysis during the procedure helped maintain muscle attachments, resulting in improved elbow function and minimal pain one year later.
This study aimed to longitudinally evaluate the development of locomotive syndrome (LS) in rheumatoid arthritis (RA) patients during the COVID-19 pandemic using the 25-question Geriatric Locomotive Function Scale (GLFS-25). Subjects were 286 RA patients (female, 70.6%; mean age, 64.
View Article and Find Full Text PDFObjectives: To investigate factors predicting frailty for one year in pre-frail patients with rheumatoid arthritis (RA).
Method: A total of 298 RA patients who were pre-frail in 2020 were evaluated in this structured, retrospective observational study. Of the 298 patients, 42 who were frail and 256 who were not in 2021 were assigned to the frailty and non-frailty groups, respectively.
Article Synopsis
- - The study compared the presence of Staphylococcus aureus nasal carriage in patients with osteoarthritis (OA) and rheumatoid arthritis (RA) undergoing total joint arthroplasty, finding that RA patients had a higher rate of carriage.
- - Among RA patients, those with moderate/high disease activity (MDA/HDA) showed a significantly greater nasal carriage rate of S. aureus compared to those with remission/low disease activity (REM/LDA).
- - Researchers concluded that preoperative nasal screening for S. aureus is particularly important in RA patients with higher disease activity to reduce the risk of surgical infections.
Objectives: Patients with rheumatoid arthritis (RA) usually switch to a second biological disease-modifying antirheumatic drugs (bDMARDs) when the first has proven to be ineffective, although some may discontinue bDMARDs treatment altogether. We investigated the total rate of bDMARDs retention and the risk of bDMARDs discontinuation in patients with RA.
Methods: The study included 564 patients with RA who started bDMARDs treatment before 2008 (<65 years old, n = 413; ≥65, n = 151).
Article Synopsis
- This study investigated how serum C-reactive protein (CRP) levels changed in rheumatoid arthritis (RA) patients before and after total knee arthroplasty (TKA), focusing on 173 patients and their 228 knees between 2006 and 2018.
- The research found that CRP levels are significantly elevated post-surgery, peaking at days 3-4 and returning to preoperative levels by day 14.
- Key factors linked to changes in CRP levels included body mass index (BMI) ≥25 and glucocorticoid usage, while other treatments like methotrexate didn't show a significant impact.
Objectives: To assess the safety and effectiveness of baricitinib treatment for rheumatoid arthritis (RA) in real-world clinical practice.
Methods: This ongoing all-case post-marketing surveillance study (starting September 2017) includes all patients with RA treated with baricitinib in Japan. Safety and effectiveness (disease activity) were assessed for 24 weeks.
Article Synopsis
- The study aimed to investigate the age of onset and initial symptoms of ankylosing spondylitis in Japanese patients, using data from 60 diagnosed individuals over a 17-year period.
- Results showed that the average age of onset was 28.9 years, with about one-third experiencing initial symptoms before age 20; the back was the most common site of symptoms.
- The findings indicated that younger patients tended to have symptoms in extra-axial joints, while the number of patients with extra-axial symptoms decreased with age.
Objectives: Persistence with treatment is key to achieving successful treatment outcomes in patients with osteoporosis. We investigated risk factors for denosumab discontinuation in patients with postmenopausal osteoporosis (PMO).
Methods: A total of 333 patients with PMO who had never received osteoporosis treatment were included in this study.
Objectives: To investigate factors associated with frailty in rheumatoid arthritis (RA) patients with decreased renal function.
Methods: RA patients who visited outpatient clinics from June to August 2021 were included (N = 625). Patients with estimated glomerular filtration rate <60 ml/min/1.
Article Synopsis
- * Of the 559 RA patients surveyed, 39.5% were found to be frail, with significantly fewer in this group rating their PtGA ≤1 compared to robust or pre-frail groups, indicating poorer self-assessment of their health.
- * The research concludes that addressing frailty, which encompasses physical, mental, and social aspects, alongside disease management, is vital for improving health assessments in RA patients.
We report a case of isolated lesions of the thoracic spine attributed to synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. A 55-year-old woman who suffered from 6 months of back pain had vertebral osteomyelitis on magnetic resonance imaging (MRI). There were no laboratory findings suggestive of infection, malignancy, or autoimmune disease.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated how well biological disease-modifying antirheumatic drugs (bDMARDs) work when taken with tacrolimus (TAC) in patients with rheumatoid arthritis, focusing on safety and effectiveness.
- - A total of 2,792 patients were included, with groups receiving either TAC, methotrexate (MTX), both, or neither. The main goal was to see how many patients had to stop treatment due to adverse events or loss of effectiveness.
- - Results showed that patients taking TAC had significantly lower rates of treatment discontinuation due to adverse events and loss of effectiveness compared to those not on TAC, indicating that TAC can be a beneficial addition to bDMARD therapy.