Publications by authors named "Nobuko Shibuya"
Purpose: This study was undertaken to assess the effects of ropivacaine on the membrane action potential and the voltage-dependent L-type calcium channel current ( I(Ca)) in guinea-pig single ventricular myocytes.
Methods: Single ventricular myocytes were prepared by enzymatic dispersion. Whole-cell current and voltage-clamp techniques were used to monitor membrane potentials and I(Ca).
Article Synopsis
- Sevoflurane induces QT interval prolongation, which was investigated using electrophysiological techniques in guinea-pig ventricular myocytes.
- The study measured various factors, including action potential duration and potassium and calcium currents, under different concentrations of sevoflurane.
- The findings showed that 2% sevoflurane significantly inhibited the delayed rectified potassium current (IKr), while having only a mild effect on the L-type calcium channel current (ICa), suggesting that the imbalance between these currents may contribute to the QT interval prolongation experienced with sevoflurane anesthesia.
Unlabelled: We indirectly assessed the in vivo effect of propofol on sympathetic neural and endothelial control of vascular smooth muscle (VSM) tone in Sprague-Dawley rats by measurement of in situ responses of VSM transmembrane potential (E(m)) in intact, small mesenteric arteries and veins superfused with physiologic salt solution. Measurements were made before, during, and after propofol infusion (10 and 30 mg x kg(-1) x h(-1)) in sympathetically innervated and locally denervated vessels. Propofol's effect on E(m) response to superfusion with acetylcholine (ACh), in physiologic salt solution also containing NG-nitro-L-arginine-methyl-ester and indomethacin, was determined in innervated vessels.
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