Publications by authors named "Nobuki Ishida"
The activation of natural killer (NK) cells in the liver inhibits engraftment of intraportally transplanted islets. We attempted to modulate the activity of NK cells by cotransplanting mesenchymal stem cells (MSCs) with islets in mice. We first investigated the ability of MSCs to secrete prostaglandin E2 , a predominant inhibitor of NK cell function, in various combinations of inflammatory cytokines.
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- The study focused on how chemotherapy affects immune cell function in patients with resectable colorectal cancer that has spread to the liver.
- Two patient groups were analyzed: one receiving adjuvant chemotherapy after liver surgery, and the other undergoing neoadjuvant chemotherapy before surgery, with comparisons made on immune cell characteristics.
- While some immune markers were higher in the neoadjuvant group, their overall immune cell function against cancer cells was similar to the adjuvant group, indicating that neoadjuvant chemotherapy might not harm the immune response in these patients.
We report a patient with advanced gastric cancer responding remarkably to neoadjuvant chemotherapy consisting of weekly paclitaxel. The patient was a 50-year-old male who had large advanced gastric cancer, suspected of invasion to the duodenum and pancreas and severe lymph node metastasis [cT4 (pancreas), cN2, cH0, cP0, cM0, cStage IV]. He was treated with weekly paclitaxel as neoadjuvant chemotherapy.
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