Publications by authors named "Nobuhito Ishii"
Article Synopsis
- The study evaluated the use of amniotic membrane (AM) transplantation in treating corneal and conjunctival diseases involving 95 eyes of 90 patients from 2007 to 2016.
- AM transplantation was performed using three different surgical techniques, showing successful outcomes such as complete healing of persistent epithelial defects and resolution of corneal perforations in most cases.
- Overall, AM transplantation proved to be effective and safe, with no complications reported in any of the cases during the treatment process.
Article Synopsis
- The study aimed to understand how fluid shear stress, similar to that caused by blinking, affects human corneal epithelial cells (HCECs).
- HCECs exposed to varying levels of shear stress showed delayed wound healing and decreased cell proliferation, along with increased TGF-β1 expression but reduced total levels in the culture.
- The findings suggest that mechanical stress influences TGF-β signaling, which plays a crucial role in wound healing, warranting further investigation into the molecular mechanisms involved.
Purpose: To compare the clinical outcomes and complications of Descemet-stripping automated endothelial keratoplasty (DSAEK) with a transscleral-sutured intraocular lens (IOL) and solitary DSAEK.
Setting: Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
Design: Retrospective case series.
Postoperative endothelial cell loss leads to graft failure after corneal transplantation, and is one of the important issues for long-term prognosis. The objective of this study was to identify clinical factors affecting graft survival and postoperative endothelial cell density (ECD) after Descemet's stripping automated endothelial keratoplasty (DSAEK). A total of 198 consecutive Japanese patients (225 eyes) who underwent DSAEK were analysed using Cox proportional hazard regression and multiple linear regression models.
View Article and Find Full Text PDFWe report a case of linezolid-induced optic neuropathy with transient microcystic spaces in the inner retina. We observed the retina using Fourier-domain optical coherence tomography (FD-OCT) in a patient with linezolid-induced optic neuropathy. A 49-year-old woman presented to our department with a 1-week history of bilateral photophobia.
View Article and Find Full Text PDFTo assess the benefits of component lamellar corneal surgery, we investigated the surgical outcomes of deep anterior lamellar keratoplasty (DALK) for keratoconus and Descemet stripping automated endothelial keratoplasty (DSAEK) for laser iridotomy-induced bullous keratopathy (LI-BK). The results were compared with the surgical outcomes of penetrating keratoplasty (PKP). Seventy-nine eyes with keratoconus treated with DALK and 81 eyes with LI-BK treated with DSAEK were studied, and the graft clarity rate, best spectacle-corrected visual acuity, endothelial cell density (ECD), and surgical complications were compared with 273 eyes with keratoconus and 98 eyes with LI-BK all treated with PKP.
View Article and Find Full Text PDFAtonic pupils after uncomplicated phacoemulsification and intraocular lens implantation.
Hokkaido Igaku Zasshi
September 2010
Objectives: An atonic pupil, defined as a dilated pupil of unknown origin, is a rare postoperative complication of ophthalmic surgery. We studied the incidence of atonic pupils after uncomplicated phacoemulsification and intraocular lens implantation (PEA+IOL) and analyzed the clinical profiles of four cases of atonic pupil.
Methods: We surveyed 54 ophthalmologists in 28 hospitals to determine their clinical experience with atonic pupils after uncomplicated PEA+IOL procedures and the total number of PEA+IOL procedures performed.