Publications by authors named "Nobuhiko Noguchi"
Background: Paliperidone is a second-generation antipsychotic and the main active metabolite of risperidone, formulated to provide consistent therapeutic effects through an extended-release system, designed to provide consistent therapeutic effects through an extended-release formulation. While commonly used in clinical practice, switching from risperidone to paliperidone, particularly during valproate therapy, can pose challenges due to potential pharmacokinetic interactions that may increase the risk of extrapyramidal symptoms (EPS). Despite clinical observations suggesting these interactions, case reports documenting such adverse effects are scarce.
View Article and Find Full Text PDFBiological aging analysis based on DNA methylation status for social anxiety disorder.
Neuropsychopharmacol Rep
December 2024
Article Synopsis
- Social Anxiety Disorder (SAD) is linked to a higher risk of aging-related diseases, and researchers used epigenetic analysis to explore this connection.
- The study analyzed DNA methylation data from 66 SAD patients and 77 controls, focusing on age acceleration and predictive values of specific proteins.
- Findings showed no significant age acceleration between groups, but indicated that leptin levels were significantly lower in SAD patients, suggesting its potential role in the disorder's development.
Falls, wheelchair dependence, and bedridden status are the results of reduced mobility in the mid-late course of dementia. Kinematic gait analysis for patients with dementia is lacking because practically setting sensors on their bodies is particularly difficult. We analyzed the parameters of kinematic gait analysis that are related to the risks of wheelchair dependence in patients with dementia using wearable accelerometers and gyroscopes for detecting 3-dimensional physical movements.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effects of two forms of aripiprazole (oral and long-acting injectable) on the autonomic nervous system (ANS) in patients with schizophrenia.
- 122 patients participated, with 72 taking oral aripiprazole and 50 receiving the once-monthly injectable version, and heart rate variability was measured to evaluate ANS activity.
- Results indicated that oral aripiprazole led to lower sympathetic nervous activity compared to the injectable version, suggesting that AOM has fewer negative effects on ANS function.