Discovery of a Phosphodiesterase 7A Inhibitor of High Isozyme Selectivity Exhibiting Anti-Osteoporotic Effects.

Phosphodiesterases (PDEs) have drawn attention due to their critical roles in physiological and pathological conditions. Many research groups have studied these hydrolytic enzymes to develop new drugs, including apremilast as a PDE4 inhibitor and sildenafil as a PDE5 inhibitor. Targeting PDE7 has also been deemed a rational strategy to ameliorate autoimmune conditions.

Injury prevention effects of stretching exercise intervention by physical therapists in male high school soccer players.

We aimed to examine the prevalence of injury after physical therapy intervention for muscle tightness and injury prevention in male high school soccer players. A randomized controlled trial was conducted. Participants comprised 124 players from two high schools who competed in national tournament soccer games held from April 2018 to March 2019.

Contributions of Muscle Elasticity and Lateral Slide of the Transversus Abdominis to Lumbar Stability.

Context: Lumbar instability can cause lumbar spondylolisthesis and chronic low-back pain in sports situation. Abdominal hollowing is commonly used in clinical practice to preferentially target the transversus abdominis (TrA) to stabilize the lumbar vertebrae; however, the contribution of muscle elasticity and lateral slide of the TrA to lumbar stability has not yet been clarified.

Objective: To clarify the contribution of elasticity and lateral slide of the TrA to lumbar stability and to identify an effective exercise to stabilize the lumbar vertebrae.

Injuries associated with Japanese high-school men's volleyball: a two-year survey and analysis.

[Purpose] There are many factors associated with sports injuries in volleyball that remain unclear; therefore, many of these injuries are still not being effectively prevented. This study aimed to help effectively prevent injuries among and provide conditioning guidance to participants of a high-school men's volleyball team. [Participants and Methods] The participants were 36 males of a high-school men's volleyball team, and the circumstances of injury occurrence, injury type, injury site, exposure time, and injury rate per 1,000 player-hours were evaluated among these participants.

Effects of second-generation histamine H1 receptor antagonists on the sleep-wakefulness cycle in rats.

The present study was performed to examine the sedative effects of second-generation histamine H(1) receptor antagonist using power spectrum analysis in the rat. Similar to ketotifen, olopatadine caused a decrease in sleep latency at a dose of 50 mg/kg, while epinastine and cetirizine showed no significant effect even at a dose of 50 mg/kg. On the other hand, no significant difference was observed in the total times of wakefulness, non-rapid eye movement sleep and rapid eye movement sleep by any drugs used in the experiments.