Novel mutations of neurofibromatosis type 1 gene in small cell lung cancers.

Purpose: Mutations in the GTPase-activating protein-related domain (GRD) of the von Recklinghausen neurofibromatosis type 1 (NF1) gene have been reported in several tumors that were not previously associated with NF1. We analyzed 37 cases of lung cancer, including 9 cases of small cell carcinoma, to detect mutations in this domain.

Methods: DNA was extracted from the tumors, and single-strand conformation polymorphism and direct sequencing were used to detect mutations.

Prognosis of non-surgically treated, clinical stage I lung cancer patients in Japan.

Objective: The optimal management of stage I lung cancer is surgical resection. However, some of these patients are not candidates for surgery because of several medical problems. We analyzed prognosis of non-surgically treated, clinical stage I lung cancer patients.