Diagnostic validity of self-reported measures of sleep bruxism using an ambulatory single-channel EMG device.

Purpose: Self-reported measures have been widely used to indicate the presence of possible and probable sleep bruxism (SB) in both research and clinical situations. However, few studies have attempted to assess the diagnostic validity of this approach. The aim of this study was to estimate the diagnostic validity of self-reported measures of SB using an ambulatory single-channel electromyographic (EMG) device.

Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells.

Sclerostin, a secreted protein encoded by the Sost gene, is produced by osteocytes and is inhibited by osteoblast differentiation and bone formation. Recently, a functional association between bone and fat tissue has been suggested, and a correlation between circulating sclerostin levels and lipid metabolism has been reported in humans. However, the effects of sclerostin on adipogenesis remain unexplored.

Symptoms and physiological responses to prolonged, repeated, low-level tooth clenching in humans.

Background: The traditional view contends bruxism, such as tooth grinding/clenching, is part of the etiology of temporomandibular disorders (TMD) including some subtypes of headaches. The purpose of this study is to investigate if a low-level but long-lasting tooth-clenching task initiates TMD symptoms/signs.

Methods: Eighteen healthy participants (mean age ± SD, 24.

Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs.

The aim of this study was to investigate the effect of tunnel structured β-tricalcium phosphate (β-TCP) on the regenerative potential of basic fibroblast growth factor-2 (bFGF-2) in class III furcation defects in dogs. The furcations of 30 mandibular premolar teeth received: 1) 0.3% bFGF-2 solution in conjunction with β-TCP; 2) 0.

A Paced Auditory Serial Addition Task evokes stress and differential effects on masseter-muscle activity and haemodynamics.

This study aimed to determine autonomic and jaw-muscle activities, and haemodynamic responses, to acute experimental mental stress in humans. Eleven healthy men (25.2 ± 3.

Site-to-site variation of muscle activity and sensitivity in the human anterior temporalis muscle: implications for contingent stimulation.

Objective: To evaluate variation of electromyographic (EMG) activity and sensitivity between different sites of anterior temporalis (AT) muscle.

Materials And Methods: Sixteen healthy subjects (eight men: 28.8 ± 5.

Corticomotor plasticity induced by tongue-task training in humans: a longitudinal fMRI study.

Corticomotor pathways may undergo neuroplastic changes in response to acquisition of new motor skills. Little is known about the motor control strategies for learning new tongue tasks. The aim of this study was to investigate the longitudinal effect of novel tongue-task training on corticomotor neuroplasticity.

Attachment formation after transplantation of teeth cultured with enamel matrix derivative in dogs.

Background: Implantation of cultured cells may be applied for periodontal regeneration in the future. However, a donor is essential in each case and tooth extraction is required to obtain the periodontal ligament-derived cell. We developed a novel regenerative technique combining tissue culture and transplantation of teeth.

[Influence of sleep bruxism on dislodgement of dental restorations].

Purpose: This study investigated the correlation between strength of sleep bruxism and dislodgement of dental restorations, by both using the facet index of occlusal splint for sleep bruxism and measuring the dislodgement rate of dental restorations.

Methods: Subjects consisted of 422 patients with 3673 dental restorations (inlay, crown, jointed crowns, and bridge) referred to the hospital from 1976 to 2004 who were randomly selected from 912 patients. All patients wore an occlusal splint during sleep.

Effects of incremental curing on contraction stresses associated with various resin composite buildups.

Objective: The purpose of this study was to photoelastically evaluate contraction stresses associated with various resin composite build-up procedures, including incremental curing and the use of flowable composite for pulpless molars.

Method And Materials: Life-sized photoelastic models of an endodontically treated molar were fabricated. The cavity represented a conservative access preparation and included four lateral walls.

Enhanced cementum formation in experimentally induced cementum defects of the root surface with the application of recombinant basic fibroblast growth factor in collagen gel in vivo.

Background: Therapies using biologically active, soluble factors such as growth factors or cytokines have been investigated for potential clinical use in regenerating lost periodontal tissue due to periodontitis. Basic fibroblast growth factor (bFGF, FGF-2) is a multifunctional growth factor that has a variety of effects including induction of proliferation and morphogenesis in a wide range of cells and tissues including periodontal ligament tissue.

Methods: In this study, we examined the effects of bFGF on the regeneration of cementum and periodontal ligament in experimentally induced partial defects in a beagle dog model.

Contraction stress of composite resin build-up procedures for pulpless molars.

Purpose: The purpose of this study was to photoelastically evaluate contraction stresses associated with various resin composite build-up procedures for pulpless molars.

Materials And Methods: Photoelastic models of endodontically treated mandibular molars were fabricated to simulate a preparation for a full-cast crown. The model configuration included three lateral walls, but no post space.

A new training device for rehabilitation of lateral mandibular movements: a pilot study.

Laterotrusive training is often used together with mouth-opening training in order to achieve adequate translation of the affected condyle in treatment of TMJ closed lock. This training is usually performed by voluntary laterotrusive movement (VLM) or by laterotrusive movement using only the fingers (FLM). However, satisfactory results are often not obtained by using these methods.

Mycoplasmal lipoproteins induce toll-like receptor 2- and caspases-mediated cell death in lymphocytes and monocytes.

Lipoproteins of Mycoplasma salivarium and Mycoplasma fermentans preferentially induced necrotic cell death in lymphocytic cell lines, MOLT-4 and Raji, and in one monocytic cell line, THP-1, whereas they preferentially induced apoptotic cell death in another monocytic cell line, HL-60. These findings were also supported by ultrastructural observations by the use of scanning and transmission electron microscopes and by agarose gel electrophoresis of the genomic DNA. The lipoproteins activated caspase-3 in both MOLT-4 and HL-60 cells, which was assessed by the cleavage of the synthetic substrate DEVD-pNA and the endogenous substrate poly(ADP-ribose) polymerase.

Pleiotrophin regulates bone morphogenetic protein (BMP)-induced ectopic osteogenesis.

We previously isolated pleiotrophin (PTN) from bovine bone as a protein and showed that it stimulated osteoblastic growth and differentiation. Further details of its function, however, have not been fully clarified. The aim of this paper was to elucidate the effects of PTN on bone morphogenetic protein (BMP)-induced ectopic osteogenesis.

Signaling pathways induced by lipoproteins derived from Mycoplasma salivarium and a synthetic lipopeptide (FSL-1) in normal human gingival fibroblasts.

Lipoproteins derived from Mycoplasma salivarium and a synthetic lipopeptide (FSL-1) activate human gingival fibroblasts to induce IL-6 production and ICAM-1 expression. Human gingival fibroblasts were treated with lipoproteins or FSL-1 and then examined for the activation of mitogen-activated protein kinases (MAPKs), ERK1/2, p38, and SAPK/JNK, and transcription factors, AP-1 and NF-kappaB. Western blotting indicated that p38 and SAPK/JNK were activated in response to the stimulators, but the activation of ERK1/2 could not be discriminated because ERK1/2 was activated in the absence of stimulators.