Publications by authors named "Nobel Chenggong Zong"
Article Synopsis
- Postoperative atrial fibrillation (POAF) and acute kidney injury (AKI) are common complications after cardiac surgery, with rates as high as 40%, and this study looked at the role of oxidative stress and inflammation in these conditions by measuring plasma nitrite and serum IL-6 levels.
- In a study of 206 cardiac surgery patients, 38% experienced POAF and 23% experienced stage 1 + AKI, with certain preoperative factors, such as age and medication use, identified as predictors for POAF, while diabetes was linked to AKI.
- The findings suggest that lower plasma nitrite levels may indicate higher oxidative stress related to POAF, and incorporating IL-6 measurements can enhance models
To this date, COVID-19 remains an unresolved pandemic, and the impairment of redox homeostasis dictates the severity of clinical outcomes. Here we examined initial UCLA cohort of 440 COVID-19 patients hospitalized between March 1 and April 1, 2020, representing the first wave of the pandemic. The mean age was 58.
View Article and Find Full Text PDFBackground: Pulmonary hypertension (PH) is a progressive disorder characterized by remodeling of the pulmonary vasculature and elevated mean pulmonary arterial pressure, resulting in right heart failure.
Methods: Here, we show that direct targeting of the endothelium to uncouple eNOS (endothelial nitric oxide synthase) with DAHP (2,4-diamino 6-hydroxypyrimidine; an inhibitor of GTP cyclohydrolase 1, the rate-limiting synthetic enzyme for the critical eNOS cofactor tetrahydrobiopterin) induces human-like, time-dependent progression of PH phenotypes in mice.
Results: Critical phenotypic features include progressive elevation in mean pulmonary arterial pressure, right ventricular systolic blood pressure, and right ventricle (RV)/left ventricle plus septum (LV+S) weight ratio; extensive vascular remodeling of pulmonary arterioles with increased medial thickness/perivascular collagen deposition and increased expression of PCNA (proliferative cell nuclear antigen) and alpha-actin; markedly increased total and mitochondrial superoxide production, substantially reduced tetrahydrobiopterin and nitric oxide bioavailabilities; and formation of an array of human-like vascular lesions.