Publications by authors named "Noam Deouell"
Ubiquitin (Ub) signals are recognized and decoded into cellular responses by Ub-receptors, proteins that tether the Ub-binding domain(s) (UBDs) with response elements. Typically, UBDs bind mono-Ub in highly dynamic and weak affinity manners, presenting challenges in identifying and characterizing their binding interfaces. Here, we report the development of a new approach to facilitate the detection of these weak interactions using split-reporter systems where two interacting proteins are proximally co-translated from a single mRNA.
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- * Researchers validated nine newly discovered short toxins that can induce cell death in both Escherichia coli and Saccharomyces cerevisiae, along with the identification of five immunity genes that protect against these toxins.
- * Some of these toxins apply significant antifungal effects against pathogenic fungi, suggesting potential applications in clinical and biotechnological fields, as further studies revealed their targeting mechanisms and DNase activity.