Examination of genetic variants involved in generation and biodisposition of kinins in patients with angioedema.

Background: Angioedema (AE) is idiopathic in the majority of cases. We studied patients with AE for genetic variants of proteins involved with bradykinin generation and biodisposition.

Methods: One hundred sixty one patients with AE were recruited at a university hospital clinic.

Effect of ketotifen premedication on adverse reactions during peanut oral immunotherapy.

Background: Oral immunotherapy (OIT) has shown promise in inducing desensitization for food allergy. However, there are safety concerns regarding the frequency and severity of adverse events during food OIT.

Objective: To evaluate the effect of Ketotifen premedication on adverse reactions during peanut OIT.

Characterization of Cannabis sativa allergens.

Background: Allergic sensitization to Cannabis sativa is rarely reported, but the increasing consumption of marijuana has resulted in an increase in the number of individuals who become sensitized. To date, little is known about the causal allergens associated with C sativa.

Objective: To characterize marijuana allergens in different components of the C sativa plant using serum IgE from marijuana sensitized patients.

Long-term efficacy of fixed-dose omalizumab for patients with severe chronic spontaneous urticaria.

Background: Treatment of chronic urticaria is challenging because many patients are refractory to or experience adverse effects with conventional therapy. Recently, short-term efficacy of omalizumab has been demonstrated.

Objective: To determine both the short- and long-term efficacy of omalizumab in the treatment of chronic urticaria.