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Publications by authors named "Noah Pena"

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Synopsis of recent research by authors named "Noah Pena"

  • - Noah Pena's recent research focuses on understanding the role of transfer RNA (tRNA) modifications and applications in genetic disease treatments, particularly how these modifications influence tRNA maturation, cellular fitness, and the development of therapeutic solutions for missense mutations.
  • - One notable study investigates the role of specific tRNA modifying enzymes, TrmA and TruB, in tRNA function and cellular fitness, revealing detrimental effects on aminoacylation when these enzymes are deleted, which emphasizes the importance of tRNA modifications in proper cellular function.
  • - Another significant contribution includes the design of a tRNA neochromosome in yeast, aimed at supporting synthetic biology efforts and expanding our understanding of tRNA functionality, along with research profiling the selective packaging of host and viral RNA in SARS-CoV-2, which broadens insights into viral biology and potential therapeutic targets.

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