Photolytic Measurement of Tissue -Nitrosothiols in Rats and Humans In Vivo.

-nitrosothiols are labile thiol-NO adducts formed in vivo primarily by metalloproteins such as NO synthase, ceruloplasmin, and hemoglobin. Abnormal -nitrosothiol synthesis and catabolism contribute to many diseases, ranging from asthma to septic shock. Current methods for quantifying -nitrosothiols in vivo are suboptimal.