Publications by authors named "Noah Mismash"
J Am Soc Mass Spectrom
September 2022
Article Synopsis
- SORI-CRAFTI is a mass spectrometry technique that activates precursor ions to measure their ion-neutral collision cross sections simultaneously with product ions.
- The method was benchmarked using protonated leucine-enkephalin, showing strong agreement (within 1-2%) with earlier results from collision-induced dissociation-ion mobility studies.
- SORI-CRAFTI demonstrated qualitative effectiveness in analyzing alkali metal-cationized leucine-enkephalin and cryptand+Cs, making it a valuable tool for exploring gas-phase ion chemistry in small to medium molecules.
J Am Soc Mass Spectrom
January 2022
Article Synopsis
- The CRAFTI technique for measuring collision cross sections (CCS) faces challenges due to the need for accurate pressure measurements in the mass spectrometer and the requirement that ions must be similar in mass to the neutral particles.
- The newly developed "multi-CRAFTI" method allows researchers to excite multiple ions simultaneously, enabling relative measurements of CCS without needing to know the exact pressure and facilitating absolute CCS measurements using internal standards.
- Experimental results show that multi-CRAFTI produces CCS values in agreement with traditional methods, although it tends to yield smaller CCS due to higher collision energies; the study indicates that computational models may overestimate interactions among the ions, particularly at higher masses.
