Publications by authors named "Noah Linhart"
Article Synopsis
- - O-linked β-N-acetylglucosamine (O-GlcNAc) is an important form of glycosylation found in many organisms, crucial for proper cellular function and linked to diseases like cancer and metabolic syndrome.
- - The study focuses on how O-GlcNAcylation affects the COPII complex, which is vital for transporting proteins from the endoplasmic reticulum in cells.
- - Researchers discovered new O-GlcNAcylation sites on key COPII proteins and suggest that this glycosylation may be influenced by nutrient levels, linking metabolism with protein trafficking in cells.
Background: Mutations in gene regulatory networks often lead to genetic divergence without impacting gene expression or developmental patterning. The rules governing this process of developmental systems drift, including the variable impact of selective constraints on different nodes in a gene regulatory network, remain poorly delineated.
Results: Here we examine developmental systems drift within the cardiopharyngeal gene regulatory networks of two tunicate species, and Cross-species analysis of regulatory elements suggests that -regulatory architecture is largely conserved between these highly divergent species.