Effect of heart rate on the pharmacokinetics of fentanyl in dogs anesthetized with isoflurane and hydromorphone.

Objective: To compare the pharmacokinetics of fentanyl at lower (LHR) or higher heart rate (HHR) in dogs anesthetized with isoflurane.

Study Design: Prospective, randomized, crossover controlled trial.

Animals: A group of six healthy 13-month-old male Beagle dogs weighing 9.

The effect of two doses of fentanyl on chest wall rigidity at equipotent doses of isoflurane in dogs.

Objective: To evaluate the effect of two doses of fentanyl upon chest wall rigidity of dogs anesthetized at equipotent doses of isoflurane [1.3 minimum alveolar concentration (MAC) of each dose of fentanyl].

Study Design: Prospective crossover randomized study.

Ultrasound-guided catheterization of the femoral artery in a canine model of acute hemorrhagic shock.

Objective: To describe a technique for gaining ultrasound-guided access to the femoral artery in an experimental model of acute hemorrhagic shock in anesthetized dogs.

Case Series Summary: Five healthy, purpose-bred adult male intact Beagles were enrolled in a respiratory mechanics study under general anesthesia. Upon completion of the primary study a hypovolemic state was induced by blood removal to achieve a mean arterial pressure ≤ 55 mm Hg.

Cardiovascular and respiratory effects of two doses of fentanyl in the presence or absence of bradycardia in isoflurane-anesthetized dogs.

Objective: To compare the cardiopulmonary effects of low and high doses of fentanyl before and after the correction of bradycardia in isoflurane-anesthetized dogs.

Study Design: Prospective, randomized crossover trial.

Animals: Eight healthy male Beagle dogs weighing 11.

Isoflurane minimum alveolar concentration sparing effects of fentanyl in the dog.

Objective: To characterize the isoflurane-sparing effects of a high and a low dose of fentanyl in dogs, and its effects on mean arterial pressure (MAP) and heart rate (HR).

Study Design: Prospective, randomized crossover trial.

Animals: Eight healthy male Beagle dogs weighing 12.

Evaluation of tissue hemoglobin saturation (StO2) using near-infrared spectroscopy during hypoxemia and hyperoxemia in Beagle dogs.

Objective: To determine the relationship between tissue oxygen saturation (StO2) and oxygen delivery (D˙O2) during hypoxemia and hyperoxemia.

Study Design: Prospective, randomized study.

Animals: Eight purpose-bred Beagle dogs.

Evaluation of tissue oxygen saturation with near-infrared spectroscopy during experimental acute hemorrhagic shock and resuscitation in dogs.

Objective: To evaluate tissue oxygen saturation (Sto2) by use of near-infrared spectroscopy in experimental acute hemorrhagic shock and resuscitation in dogs.

Animals: 14 healthy adult purpose-bred Beagles.

Procedures: Dogs were anesthetized with isoflurane via facemask, anesthesia was maintained with propofol and rocuronium bromide, and dogs were mechanically ventilated to maintain normocapnia.