Publications by authors named "Noah Connally"
Article Synopsis
- Autoimmune and inflammatory diseases involve multiple genes and often share risk alleles, making it tough to pinpoint specific causes.
- A study analyzing over 129,000 cases and controls found that about 40% of related genetic associations come from the same genetic variants across six different diseases.
- By improving the resolution of genetic mapping, the researchers could identify more related gene expressions, suggesting that while there are common mechanisms between these diseases, there isn't just one universal cause for all autoimmune diseases.
Article Synopsis
- The genetic basis of traits is mainly polygenic and influenced by non-coding alleles, which are thought to have minor regulatory roles in gene expression.
- Despite having access to extensive gene expression and epigenomic data, few connections between genetic variants and gene activity have been established.
- A study identified 220 gene-trait pairs influenced by protein-coding variants, revealing little evidence that typical gene expression explains associations with complex traits, indicating a need for improved models to understand these complexities.
Blebbistatin reversibly disrupted both stolon tip pulsations and gastrovascular flow in the colonial hydroid Podocoryna carnea. Epithelial longitudinal muscles of polyps were unaffected by blebbistatin, as polyps contracted when challenged with a pulse of KCl. Latrunculin B, which sequesters G actin preventing F actin assembly, caused stolons to retract, exposing focal adhesions where the tip epithelial cells adhere to the substratum.
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