Publications by authors named "Noa A Linthorst"
Article Synopsis
- The study looks at a protein called Von Willebrand factor (VWF) that is important for blood clotting and how it can cause problems when it's not working right.
- Researchers used special tiny molecules called siRNAs to selectively reduce VWF levels in mice with different versions (alleles) of the VWF gene.
- The results showed that reducing VWF helped prevent blood clots without causing bleeding issues, suggesting this method could be useful for treating certain blood disorders.
An imbalance in von Willebrand factor (VWF) may either lead to bleeding (von Willebrand disease, VWD) or thrombosis. Both disorders have shortcomings in the currently available treatments. VWF itself could be a potential therapeutic target because of its role in both bleeding and thrombosis.
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