Publications by authors named "Nnamdi Azih"
Equipoise remains about how best to measure cardiac output (CO) in patients with left ventricular assist devices (LVAD). In this study, direct Fick CO was compared with thermodilution (TD) and indirect Fick (iFick) CO in 61 LVAD patients. TD and LaFarge iFick showed moderate correlation with direct Fick (R = 0.
View Article and Find Full Text PDFLate right heart failure (LRHF) following left ventricular assist device (LVAD) implantation remains poorly characterized and challenging to predict. We performed a multicenter retrospective study of LRHF in 237 consecutive adult LVAD patients, in which LRHF was defined according to the 2020 Mechanical Circulatory Support Academic Research Consortium guidelines. Clinical and hemodynamic variables were assessed pre- and post-implant.
View Article and Find Full Text PDFHemodynamic reserve predicts early right heart failure after LVAD implantation.
J Heart Lung Transplant
December 2022
Background: Early right heart failure (RHF) remains a major source of morbidity and mortality after left ventricular assist device (LVAD) implantation, yet efforts to predict early RHF have proven only modestly successful. Pharmacologic unloading of the left ventricle may be a risk stratification approach allowing for assessment of right ventricular and hemodynamic reserve.
Methods: We performed a multicenter, retrospective analysis of patients who had undergone continuous-flow LVAD implantation from October 2011 to April 2020.
Article Synopsis
- The function and phenotype of macrophages are influenced by their microenvironment, and chronic alcohol consumption can disrupt their ability to respond as innate immune cells.
- Previous studies indicate that alcohol intake leads to a reduced capacity for macrophages to handle oxidative stress, prompting research into how macrophage polarization affects this response.
- Experiments showed that IFN-γ-polarized macrophages (M1) demonstrate a stronger ability to scavenge reactive oxygen species and involve the upregulation of key proteins like Nrf2, which is crucial for the antioxidant response and macrophage polarization, highlighting its importance in immune function.