Publications by authors named "Nna-Emeka Ejimogu"
Background And Objectives: Patients undergoing percutaneous rhizotomy for trigeminal neuralgia (TN) may require several procedures to manage their pain. However, it is not fully understood whether repeat procedures influence postoperative complication rates.
Methods: We retrospectively reviewed patients undergoing rhizotomy at our institution from 2011 to 2022.
Article Synopsis
- Doctors studied two treatments for a type of pain called TN. One is called SRS, and the other is glycerol rhizotomy. They wanted to see if having SRS first affects how well the rhizotomy works.
- They looked at data from patients treated at their hospital between 2011 and 2022. They compared patients who had SRS before rhizotomy with those who only had the rhizotomy.
- Results showed that patients who had SRS were more likely to continue feeling pain after the rhizotomy, especially soon after the surgery. They also found that older patients had better chances of success with the rhizotomy.
Article Synopsis
- This study examines the impact of two hemodialysis methods—continuous venovenous hemodialysis (CVVHD) and intermittent hemodialysis (iHD)—on the rates of subdural hematoma (SDH) re-expansion in patients with end-stage renal disease (ESRD).
- Researchers found that patients undergoing CVVHD had lower rates of SDH expansion affecting neurological function compared to those on iHD, highlighting a significant difference in outcomes between the two methods.
- The conclusion suggests that CVVHD may provide better stability for SDH in ESRD patients, indicating a potential preference for this dialysis approach in their treatment.
Eukaryotic arginylation is an essential post-translational modification that modulates protein stability and regulates protein half-life. Arginylation is catalyzed by a family of enzymes known as the arginyl-tRNA transferases (ATE1s), which are conserved across the eukaryotic domain. Despite their conservation and importance, little is known regarding the structure, mechanism, and regulation of ATE1s.
View Article and Find Full Text PDFEukaryotic post-translational arginylation, mediated by the family of enzymes known as the arginyltransferases (ATE1s), is an important post-translational modification that can alter protein function and even dictate cellular protein half-life. Multiple major biological pathways are linked to the fidelity of this process, including neural and cardiovascular developments, cell division, and even the stress response. Despite this significance, the structural, mechanistic, and regulatory mechanisms that govern ATE1 function remain enigmatic.
View Article and Find Full Text PDFMutations in the RNA helicase, , are a leading cause of Intellectual Disability and present as syndrome, a neurodevelopmental disorder associated with cortical malformations and autism. Yet, the cellular and molecular mechanisms by which DDX3X controls cortical development are largely unknown. Here, using a mouse model of loss-of-function we demonstrate that DDX3X directs translational and cell cycle control of neural progenitors, which underlies precise corticogenesis.
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