A randomized, double-blind, placebo-controlled Phase II extended safety study of two Invisible Condom formulations in Cameroonian women.

Background: Invisible Condom gel formulations being developed as microbicides to prevent the sexual transmission of HIV are advancing through the phases of clinical trials. The objectives of this study were to evaluate, after 8 weeks of vaginal application, the extended safety and acceptability of two Invisible Condom vaginal gel formulations: (i) the polymer alone and (ii) the polymer containing sodium lauryl sulfate (SLS) compared to placebo.

Study Design: This study is a randomized, doubled-blind, placebo-controlled Phase II extended safety study in healthy sexually active women from Yaoundé, Cameroon.

A randomized, double-blind, placebo-controlled safety and acceptability study of two Invisible Condom formulations in women from Cameroon.

Background: The objectives of this clinical trial were to evaluate the safety, tolerance and acceptability of two gel formulations of the Invisible Condom: (i) the polymer alone and (ii) the polymer-containing sodium lauryl sulfate (SLS) compared to placebo when applied intravaginally with our unique applicator in sexually abstinent and active woman volunteers.

Study Design: A randomized, doubled-blind, placebo-controlled study in healthy women from Yaoundé, Cameroon. Two hundred sixty women were randomized into three gel arms: (a) gel alone, (b) gel plus SLS and (c) placebo gel.

Safety and acceptability of 6% cellulose sulfate vaginal gel applied four times per day for 14 days.

Background: Six percent cellulose sulfate (CS) is a vaginal gel that has been in development as a microbicide.

Study Design: This was a single-center, multi-dose, Phase I, placebo-controlled, randomized, fully masked study conducted in Yaoundé, Cameroon, and involving sexually active women at low risk for sexually transmitted infections (STIs).

Methods: The study assessed the effect of CS and K-Y Jelly applied vaginally four times per day, for 14 consecutive days, on genital epithelial disruption, candidiasis and bacterial vaginosis (BV).

Management of tubal obstructions.

Management of the tubal factor could have the most difficult and debatable role in infertility management. The methods used ranged from gaseous insufflation, hydrotubation, laparotomy, and traditional microsurgery to the more recent tactile or hysteroscopic catheterization, and laparoscopic surgery. Results of the in-vitro-fertilization-embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI) were compared to the surgical procedures' results and the debate continues: shall we proceed directly to assisted reproductive techniques or should surgery be tried first in tubal obstructions?