Publications by authors named "Nkechinyere J Uche"
Background: Genomic research advances the understanding of human health and disease. It also drives both the discovery of salient genetic association(s) as well as targeted screening, diagnostic and therapeutic strategies. Human subject participation is crucial for the success of genomic research.
View Article and Find Full Text PDFBackground: Orbito-ocular tumors are rare, but they cause significant morbidity and mortality. There are reported variations in their pattern of presentation and frequency of occurrence.
Objective: To evaluate the occurrence, clinico-pathologic spectrum, and patterns of orbito-ocular neoplasms as well as the treatment and outcome profiles.
Purpose: To report clinical features and treatment outcomes of primary combined trabeculotomy with trabeculectomy (CTT) in congenital aniridia with glaucoma in children 3 years of age or younger.
Design: Retrospective study.
Participants: Sixty-six eyes of 35 children with congenital aniridia and early-onset glaucoma who underwent CTT between May 1997 and June 2015 were included.
Objective: To evaluate the current status of pediatric brain tumor (PBT) care and identify determinants and profiles of survival and school attendance.
Methods: An 8-year institution-based prospective longitudinal study. All cases investigated with neuroimaging and treated were enrolled.
Article Synopsis
- Primary open-angle glaucoma is more common and severe in people of African descent compared to those of European or Asian ancestry, yet they are often overlooked in genetic research on this condition.
- The study conducts a genome-wide association study (GWAS) involving nearly 10,000 participants from various countries to identify genetic links to the disease.
- Results suggest significant genetic variants associated with primary open-angle glaucoma, highlighting the need for more focused research on affected populations for better understanding and treatment options.
Background: Endoscopic third ventriculostomy (ETV) and ventriculo-peritoneal shunt (VPS) although recognized surgical options for non-communicating hydrocephalus have debatable applications.
Objective: We analysed a prospective cohort of age-matched children with non-tumor, non-communicating hydrocephalus treated with the two surgical modalities using clinically measurable parameters.
Methods: A single institution analysis of age-matched patients with non-communicating hydrocephalus treated with VPS or ETV over a 3-year period.