Chitosan-Based Microparticle Encapsulated Phage Cocktail in Hydrogel Matrix for the Management of Multidrug Resistant Chronic Wound Infection.

Objectives: Multi-drug resistant bacteria have been implicated in various debilitating infections that have led to life loss. This study developed an approach to tackle multidrug resistant infection in a chronic wound model through phage encapsulation with resuspension in hydrogel.

Materials And Methods: Two isolates of -specific lytic phases ɸAB140 and ɸAB150 alone, in combination (cocktail) encapsulated within a chitosan (CS) microparticle was suspended in CS hydrogel and evaluated for their therapeutic efficacy to ensure bacterial clearance in induced diabetic wound infection.

Genetics of bi-component leukocidin and drug resistance in nasal and clinical Staphylococcus aureus in Lagos, Nigeria.

Background: Resistant and virulent Staphylococcus aureus is a global public health challenge. Staphylococcal Bi-component leukotoxins are cytolytic to immune cells and evolve to disarm the innate immunity during infections, hence the severity of the disease.

Objective: We studied drug resistance profile and the occurrence of bi-component leukocidin in clinical and nasal S.