Multidrug-Resistant and Extremely Drug-Resistant in Clinical Samples From a Tertiary Healthcare Facility in Nigeria.

Objectives: has been globally implicated in healthcare-associated infection. The susceptibility pattern of clinical isolates of to anti-pseudomonal antibiotics is reported.

Materials And Methods: Clinical samples, namely blood, urine, tracheal aspirate, cerebrospinal fluid (CSF), wound swabs, high vaginal swabs, eye, and ear exudates were obtained from patients, processed and identified using standard microbiological protocols.

Farnesol inhibits translation to limit growth and filamentation in and .

is a polymorphic yeast where the capacity to switch between yeast and filamentous growth is critical for pathogenicity. Farnesol is a quorum-sensing sesquiterpene alcohol that, via regulation of specific signalling and transcription components, inhibits filamentous growth in . Here we show that farnesol also inhibits translation at the initiation step in both and .

Alcohols inhibit translation to regulate morphogenesis in C. albicans.

Many molecules are secreted into the growth media by microorganisms to modulate the metabolic and physiological processes of the organism. For instance, alcohols like butanol, ethanol and isoamyl alcohol are produced by the human pathogenic fungus, Candida albicans and induce morphological differentiation. Here we show that these same alcohols cause a rapid inhibition of protein synthesis.