Publications by authors named "Njabulo Xulu"
Article Synopsis
- The study explores how levels of mature brain-derived neurotrophic factor (mBDNF) and its precursor, proBDNF, relate to cognitive function in HIV-positive adults in sub-Saharan Africa who haven't started antiretroviral therapy (ART).
- Increased mBDNF levels were positively associated with better cognitive performance, while higher proBDNF levels correlated with poorer cognitive outcomes, especially affecting fine motor skills.
- The research suggests that mBDNF and proBDNF play different roles in cognitive health for those with HIV, indicating a need for further studies to understand their impact during ART initiation and how they could guide neurocognitive interventions.
Background: Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-associated neurocognitive impairment persists. We investigated the association between serum levels of mature brain-derived neurotrophic factor (mBDNF), precursor brain-derived neurotrophic factor (proBDNF), and neurocognitive changes over time among adults with HIV in sub-Saharan Africa, seeking to elucidate the interplay between neurotrophic factors and neurocognitive outcomes post-ART.
Methods: Utilizing data from the ACTG 5199 study in Johannesburg and Harare, serum mBDNF and proBDNF levels were measured via enzyme-linked immunosorbent assay.