Use of transforming growth factor-β loaded onto β-tricalcium phosphate scaffold in a bone regeneration rat calvaria model.

Background: Transforming growth factor-β (TGF-β ) enhances mesenchymal stem cell (MSC) differentiation into osteoblasts.

Purpose: The aim of the study was to assess whether TGF-β loaded onto β-tricalcium phosphate (β-TCP) synthetic scaffold enhances bone regeneration in a rat calvaria model. The release kinetics of TGF-β from β-TCP scaffold was evaluated in vitro.

Adult stem cells in the use of jaw bone regeneration: current and prospective research.

Concomitant to the increased use of dental implants to replace lost dentition, there is a growing need to regenerate atrophic jaw bone to allow dental implant placement. Current surgical techniques for jaw bone augmentation share several limitations, such as operator sensitivity and relatively low predictability and high morbidity rates. Therefore, alternative treatment approaches have been developed in the field of tissue engineering.