Publications by authors named "Nizar Hakam"
Importance: Several public recommendations exist regarding the amount of daily water intake, yet the supporting evidence is not clear, and benefits of increasing water consumption are not well-established.
Objective: To summarize evidence from randomized clinical trials (RCTs) pertaining to the health-related outcomes associated with increased or decreased daily water consumption.
Evidence Review: A systematic search of PubMed, Web of Science, and Embase was performed up to April 6, 2023.
Background: Consumer product-related genital injuries in females across all age groups are understudied. Existing research focuses primarily on paediatric populations. We aimed to determine characteristics, trends and predictors of hospitalisation.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed data from the National Trauma Databank (2017-2020) to understand the characteristics of genitourinary self-inflicted injuries (GU SII) and compare differences between genders.
- Out of 56,463 SII cases, 1508 (2.7%) involved GU injuries, with a majority being young white males (77.3%), and kidney injuries were the most common.
- Many patients had pre-existing mental health issues (54.9%), and despite a high survival rate, 15.4% of cases were fatal, particularly those with kidney injuries and other non-GU injuries.
Article Synopsis
- The study compares Fournier gangrene between female and male patients, using data from the National Inpatient Sample from 2016 to 2020, to identify factors related to mortality in both groups.
- It found that a higher percentage of females (7.1%) died from the condition compared to males (5.7%), and that females experienced longer hospital stays and more severe complications.
- Key factors affecting mortality included the time until initial treatment and race, with diabetes found to lower mortality odds for both genders, highlighting the need for timely intervention in female patients.
Article Synopsis
- A population-based analysis was conducted using National Inpatient Sample data from 2016-2020 to compare risk factors and mortality rates associated with Fournier's gangrene and perineal cellulitis.
- The study identified significant associations between Fournier's gangrene and factors such as Native American race, diabetes, malignancy, and seasonal admissions, while certain racial groups and higher income decreased the likelihood of this condition.
- Increased mortality risks in Fournier's gangrene patients were linked to female gender, Native American ethnicity, and the frequency of medical procedures, highlighting the need for better care access and understanding of the condition for improved patient outcomes.
Ejaculatory function after radiotherapy for prostate cancer: a systematic review and meta-analysis.
Prostate Cancer Prostatic Dis
September 2024
Background: Scant data exists on the impacts of prostate radiation on ejaculatory function. We performed a systematic review and meta-analysis to assess ejaculatory outcomes in men after prostate radiation.
Methods: We queried PubMed, Embase, and Web of Science to identify 17 articles assessing ejaculatory function post-radiation.
Importance: Micromobility, the use of small vehicles (primarily scooters and bicycles), has become a standard transportation method in the US. Despite broad adoption of electric micromobility vehicles, there is a paucity of data regarding the injury profiles of these vehicles, particularly in the US.
Objective: To characterize micromobility injury trends in the US, identify demographic characteristic differences in users of electric and conventional vehicles, and identify factors associated with hospitalization.
Introduction: Patient perceptions of physician reimbursement commonly differ from actual reimbursement. This study aims to improve health care cost transparency and trust between patients, physicians, and the health care system by evaluating patient perceptions of Medicare reimbursement for artificial urinary sphincter (AUS) placement.
Methods: We identified patients who underwent AUS placement at a single institution from 2014 to 2023.
Purpose: Overactive bladder (OAB) syndrome significantly impairs quality of life, often necessitating pharmacological interventions with associated risks. The fragility of OAB trial outcomes, as measured by the fragility index (FI: smallest number of event changes to reverse statistical significance) and quotient (FQ: FI divided by total sample size expressed as a percentage), is critical yet unstudied.
Materials And Methods: We conducted a systematic search for randomized controlled trials on OAB medications published between January 2000 and August 2023.
Purpose: We evaluate the efficacy and safety profiles of currently available conservative management options for penile and urethral lichen sclerosus.
Materials And Methods: A systematic review of existing literature on lichen sclerosus was conducted utilizing the PubMed, Embase, and Web of Science databases. References were assessed for relevance to nonsurgical management of male genital lichen sclerosus by title and abstract by 3 independent reviewers, then reviewed in full and in duplicate by 5 independent reviewers.
Oral phosphodiesterase type 5 inhibitors and priapism: A VigiBase analysis.
Pharmacoepidemiol Drug Saf
January 2024
Purpose: To explore the differences of priapism events among a diverse cohort taking erectogenic medicines (i.e., phosphodiesterase type 5 inhibitors [PDE5i] and intracavernousal drugs).
View Article and Find Full Text PDFObjective: To characterize adverse events related to use of the perirectal spacing agent SpaceOAR, we examined the Manufacturer and User Facility Device Experience (MAUDE) database.
Methods: The MAUDE database was queried for "SpaceOAR" and "Augmenix" from June 2015 (when SpaceOAR was approved by the Food and Drug Administration) to October 2022. Reports were reviewed for adverse events (AEs), operative procedures performed because of the AE, and changes to the radiation plan.
Objective: To systematically compare success, cure and complication rates of urethral sling surgeries in stress urinary incontinence patients with and without a history of pelvic radiotherapy (RT).
Materials And Methods: We searched PUBMED, EMBASE, and Web of Science to identify relevant articles. The primary outcomes were the success and cure rates.
Haemorrhagic cystitis (HC) is characterised by persistent haematuria and lower urinary tract symptoms following radiotherapy or chemotherapy. Its pathogenesis is poorly understood but thought to be related to acrolein toxicity following chemotherapy or fibrosis/vascular remodelling after radiotherapy. There is no standard of care for patients with HC, although existing strategies including fulguration, hyperbaric oxygen therapy, botulinum toxin A, and other intravesical therapies have demonstrated short-term efficacy in cohort studies.
View Article and Find Full Text PDFPurpose: To investigate management trends for American Association for the Surgery of Trauma (AAST) grade V renal trauma with focus on non-operative management.
Methods: We used prospectively collected data as part of the Multi-institutional Genito-Urinary Trauma Study (MiGUTS). We included patients with grade V renal trauma according to the AAST Injury Scoring Scale 2018 update.
Introduction: To evaluate the clinical characteristics as well as the postoperative course of urolithiasis patients undergoing a ureteroscopy (URS) without stent placement.
Materials And Methods: This was a prospective case cohort study utilizing data collected in the Registry for Stones of the Kidney and Ureter (ReSKU) from a single institution between October 2015 and December 2020. We identified all consecutive patients undergoing URS for stone disease and analyzed data encompassing demographics, medical history, intra and postoperative characteristics, including complications and postoperative symptoms.
Objectives: Over the past 20 years, the utility of partial nephrectomy (PN), compared to radical nephrectomy (RN), for the management of localized renal cell carcinoma (RCC) has progressively increased, particularly for larger and more complex masses. We sought to compare the recurrence-free survival (RFS) outcomes of PN versus RN in a single-institution cohort.
Methods: Between 2002 and 2017, 228 patients underwent RN or PN for lcT1a-T2b, N0M0 RCC at a single tertiary referral center, performed by five surgeons.
Objective: To understand the effect of bicycle saddle shape and size on the pressure transmitted to the perineum, as prolonged perineal pressure and microtrauma amongst avid cyclists may increase the risk for complications following lower genitourinary surgery.
Methods: We tested five seats (Bontrager, Waterloo, WI) with varying levels of padding and morphology (comfort, fitness, fitness gel, race, and performance) for two different riders. The seats were installed on a Peloton stationary exercise bike (New York City, NY).
Introduction: Our primary aim was to characterize eventual publication of presented American Urological Association (AUA) Annual Meeting oncology abstracts from 1997 to 2017. We hypothesized that the percentage of abstracts presented at the AUA Annual Meeting that became published peer-reviewed manuscripts increased over time.
Methods: AUA Annual Meeting abstracts in "oncology" categories from 1997 to 2017 were identified.
Outcomes after ultrasound-only percutaneous nephrolithotomy (PCNL), in which no fluoroscopy is used, are not well known. The goal of this study was to compare outcomes of ultrasound-only and fluoroscopy-directed PCNL. Prospectively collected data from the Registry for Stones of the Kidney and Ureter database were reviewed for all patients who underwent PCNL at one academic center from 2015 to 2021.
View Article and Find Full Text PDFObjective: To systematically aggregate and summarize existing data on fistula prevalence among patients with a history of pelvic radiotherapy for prostate cancer.
Materials And Methods: We queried PubMed, Embase, and Web of Science on October 7, 2020 for peer-reviewed publications pertaining to radiation-induced fistulas in the pelvis. For meta-analysis, we used the random-effects model.
Background: Despite their efficacy and general safety, rare but devastating adverse drug reactions have been associated with phosphodiesterase type 5 inhibitors.
Objectives: To determine the safety profile of oral phosphodiesterase type 5 inhibitors with a particular focus on priapism and malignant melanoma.
Materials And Methods: In this case-non-case study, we queried the individual case safety reports for phosphodiesterase type 5 inhibitors within the World Health Organization global database of individual case safety reports (VigiBase) between 1983 and 2021.