Publications by authors named "Niyeti Qazi"
Background: Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson's disease (PD). Various molecular, clinical and genetic studies have highlighted a central role of lysosomal pathways and proteins in the pathogenesis of PD. Within PD pathology the synaptic protein alpha-synuclein (αSyn) converts from a soluble monomer to oligomeric structures and insoluble amyloid fibrils.
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- Researchers found that a substance called CCL18 from special brain cells called GAMs helps glioblastoma multiforme (a type of brain cancer) to grow and spread.
- They created a way to study CCL18 using human brain cells in mice to see how it works, since it’s not found in mouse cells.
- They discovered that CCL18 helps glioma cells grow by using a specific receptor (CCR8) and acts through another molecule (ACP5) to cause this growth.