Publications by authors named "Nixin Tian"
Article Synopsis
- * A novel miR-nanosponge has been created to simultaneously capture multiple miRs linked to GBM growth and spread, improving therapeutic outcomes by addressing the cancer's compensatory mechanisms.
- * This miR-nanosponge, coated with BV2 cell membranes to better penetrate the blood-brain barrier, has shown to significantly prolong survival in GBM-bearing mice, surpassing the effectiveness of the standard drug temozolomide (TMZ).
Article Synopsis
- Glioblastoma (GBM) is a highly aggressive brain tumor challenging to treat due to the blood-brain barrier and the tumor's immunosuppressive environment.
- A novel immunotherapy strategy using a nanomaterial called BM@MnP-BSA-aPD-1 has been developed, which effectively crosses the blood-brain barrier and targets the tumor microenvironment.
- This approach enhances anti-tumor immunity through various mechanisms, including activating specific immune pathways and inhibiting immune evasion signals, showing promise for clinical use in GBM treatment.
