Cholesterol Depletion Activate Hepatic Stellate Cells Mediated Through SREBP-2 Signaling.

Liver fibrosis is one of the leading cause of death worldwide. In liver, hepatic stellate cells are the primary cell type that gets activated during fibrosis. LX-2 cells are human-derived hepatic stellate cell lines typically employed for studying liver fibrosis mechanisms and screening anti-fibrotic lead molecules.

Inhibition of hepatic stellate cell activation by nutraceuticals: an emphasis on mechanisms of action.

Liver diseases emerge as a serious threat to humans worldwide due to increasing morbidity and mortality. Liver disease related deaths accounts for one third of all disease related death globally. A simple fatty liver if unattended advances further to liver fibrosis, cirrhosis and hepatocellular carcinoma.

A critical review on anti-fibrotic phytochemicals targeting activated hepatic stellate cells.

Liver fibrosis is a major health concern occurring worldwide. It arises due to prolonged wound healing response of various insults like viral, autoimmune, cholestatic, drug-induced, and metabolic diseases. Currently, there is no clinically approved drug for liver fibrosis treatment.