[Treatment of local Hodgkin's disease with massive mediastinal involvement].

Aim: To define the scope of combined therapy in patients having local Hodgkin's disease (LHD) with massive mediastinal lesion.

Material And Methods: From 1980 to 1997 the treatment was given to 75 LHD patients with massive lesion of the mediastinum (mediastinal-thoracic index, MTI, > or = 0.33).

[Potentials and outlook for radiation therapy of cancer patients on an outpatient basis].

The paper is devoted to the problems of the organization of radiotherapy in an outpatient setting. Irradiation outside a hospital was demonstrated on 2500 patients with different primary and metastatic tumor lesions by way of an example. Social and economic advantages of this type of care were shown.

[Conservative treatment of breast cancer].

The paper is concerned with clinical characterization of 81 breast cancer patients after conservative radio- and hormonotherapy. Of the total number of patients 47 suffered from inoperable tumors as a result of local spreading, 30 patients had serious contraindications for the operation, and 4 patients refused surgical intervention. Of the total number of patients 85% were aged over 50, 69%--over 60.

[An experience with the conservative treatment of breast cancer in middle-aged and elderly women].

Advantages of conservative treatment of inoperable breast cancer in old and elderly age are discussed on the basis of an analysis of data on 30 cases. A split-course radical radiotherapy was combined with a prolonged tamoxifen treatment. Complete regression of tumor was registered in 16 out of 23 followed-up patients, while more than 50% regression--in I case.

[Complex therapy of melanoma metastases in the lung].

The authors present the therapeutic results of 25 patients with melanoma metastases of the lungs: 9 of them received radiotherapy only, 16 radiotherapy combined with i.v. injection of the antitumor antibiotic dactinomycin.

[Adriamycin (doxorubicin) in the combined treatment of patients with the edematous-infiltrative form of breast cancer].

Twenty-one female patients with edematous infiltrative cancer of the breast without distant metastases not given specific therapy before were treated with vincristine, adriamycin, methotrexate and irradiation of the mammary glands and regional areas in accordance with the splitted course procedure. If the positive estrogen receptors were present in the tumor tissue, the patients with preserved menstrual function and menopause of not more than 5 years were subjected to ovariectomy. The suggested induction scheme of the treatment provided pronounced objective results in 80.

[Radiation and combination treatment of breast cancer metastases to the lungs].

The authors describe methodological and clinical results of the so-called large field irradiation of 56 patients with breast cancer metastases to the lungs. Of these, 46 received radiotherapy alone, 10 radiotherapy in combination with polychemotherapy using the CMF scheme (cyclophosphamide, methotrexate and 5-fluorouracil). As a result of radiotherapy (46 women), a noticeable objective response was achieved in 44% of the cases; among 10 patients on multimodality therapy it was achieved in 4.

[Conservative methods of treating breast cancer metastases to the lungs].

An analysis is presented of different routine methods of treatment (radiotherapy, mono- and polychemotherapy; chemo-radiation treatment) used in 77 patients with breast cancer metastases in the lung. According to the data obtained positive results were gained in 53% of cases, a considerable effect being noted in 46% of patients.

[Radiotherapy of metastases of malignant neoplasms into the lungs].

The results of radiation therapy in 800 patients with lung metastases of different malignant neoplasms are reported. Metastases were multiple--in 53 cases, single--in 7, solitory--in 14. In 6 patients metastatic nodes were noted in the pleura.

[Palliative radiation therapy of malignant tumor metastases to the bones].

The results obtained in irradiation of 106 patients with metastases of different malignant tumors in the skeleton are reported. Radiotherapy was carried out on a distance gamma-apparatus by two fractions, with a single dose of 650 or 850 rad. As a result of the therapy, pains disappeared in 32 patients, and in 60 patients these were diminished considerably.

[Chemoradiation therapy of inoperable lung cancer].

The results of utilization of different variants of the complex therapy in 416 patients with inoperable lung cancer are reported. 5-fluoruracil, cyclophosphan, methotrexate, chrysomallin were employed as antitumor drugs. Radiotherapy was carried out on a distance gamma machine.