Salivary interleukin-10 and interleukin-17 - Potential biomarkers for assessing oral cancer and oral potentially malignant disorders - A comparative study.

Background: Staging of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) is considered as the most important prognostic indicator, but salivary proteins such as interleukins (ILs) can serve as potential biomarkers. The aim of this study was to assess the presence of salivary IL-10 and IL-17 in OSCC and OPMD (oral submucous fibrosis and oral leukoplakia).

Materials And Methods: This was a hospital-based, in vivo, cross-sectional, comparative study.

Emerging pharmacotherapy trends in preventing and managing oral mucositis induced by chemoradiotherapy and targeted agents.

Introduction: The introduction of targeted therapy and immunotherapy has tremendously changed the clinical outcomes and prognosis of cancer patients. Despite innovative pharmacological therapies and improved radiotherapy (RT) techniques, patients continue to suffer from side effects, of which oral mucositis (OM) is still the most impactful, especially for quality of life.

Areas Covered: We provide an overview of current advances in cancer pharmacotherapy and RT, in relation to their potential to cause OM, and of the less explored and more recent literature reports related to the best management of OM.