Publications by authors named "Nivedita Patil"
Article Synopsis
- Lignocellulosic biomass is tough to break down enzymatically, leading to high costs in biofuel production due to the need for large amounts of enzymes.
- Researchers are exploring "supercharging" enzymes by altering their surface charge to improve their efficiency against plant cell wall components, though past efforts have had limited success.
- A study designed a library of mutant endoglucanases with varying charges and found that certain mutations significantly enhanced enzyme activity—up to a 5-fold increase—especially those altering the carbohydrate-binding module, also showing increased optimal temperatures for hydrolysis.
Purpose: To evaluate the learning curve of continuous curvilinear capsulorhexis (CCC) and to assess the number of surgeries required to master it among residents in a postgraduate teaching institute.
Methods: The present prospective observational study was based on the completion time and complication rates related to CCC performed using various techniques by 10 students in the 2 (JR2) and 3-year (JR3) of residency. CCC was performed either by a cystotome or capsulorhexis forceps or by a combined method in 253 eyes, of which 160 eyes (63.
Surfactants with their intrinsic ability to solubilize lipid membranes are widely used as antibacterial agents, and their interactions with the bacterial cell envelope are complicated by their differential aggregation tendencies. We present a combined experimental and molecular dynamics investigation to unravel the molecular basis for the superior antimicrobial activity and faster kill kinetics of shorter-chain fatty acid surfactant, laurate, when compared with the longer-chain surfactants studied in contact time assays with live (). From all-atom molecular dynamics simulations, translocation events across peptidoglycan were the highest for laurate followed by sodium dodecyl sulfate, myristate, palmitate, oleate, and stearate.
View Article and Find Full Text PDFAim: To assess the incidence of vitreous loss and associated risk factors in residents performing manual small-incision cataract surgery (MSICS).
Methods: The present retrospective record review study was performed on 490 patients who underwent MSICS performed between November 2018 and December 2019 by 7 third-year postgraduate residents. The study group comprised of patients having intraoperative vitreous prolapse.
Computerized tomography (CT) is an invaluable imaging investigation for evaluating COVID-19 disease. CT detects early changes of COVID-19 pneumonia and predicts the disease prognosis based on a semiquantitative 25-point CT severity score (CT-SS). India launched its vaccination drive in January 2021 with two different vaccines being approved by the government.
View Article and Find Full Text PDFMultisystem inflammatory syndrome in children (MIS-C) is a post-infectious immune-mediated condition, seen 3-5 weeks after COVID-19. Maternal SARS-CoV-2 may potentially cause a similar hyperinflammatory syndrome in neonates due to transplacental transfer of antibodies. We reviewed the perinatal history, clinical features, and outcomes of 20 neonates with features consistent with MIS-C related to maternal SARS-CoV-2 in Kolhapur, India, from 1 September 2020 to 30 April 2021.
View Article and Find Full Text PDFThe bacterial cell envelope is a complex multilayered structure evolved to protect bacteria in hostile environments. An understanding of the molecular basis for the interaction and transport of antibacterial therapeutics with the bacterial cell envelope will enable the development of drug molecules to combat bacterial infections and suppress the emergence of drug-resistant strains. Here we report the successful creation of an in vitro supported lipid bilayer (SLB) platform of the outer membrane (OM) of , an archetypical Gram-negative bacterium, containing the full smooth lipopolysaccharide (S-LPS) architecture of the membrane.
View Article and Find Full Text PDFObjectives: To evaluate the perinatal outcome with the abnormal umbilical cord coiling index.
Study Design: This prospective study was carried out in the department of OBG at Adichunchangiri Institute of Medical Sciences, B.G.