Rationale: Pancreatic mixed serous neuroendocrine neoplasm (PMSNN) is an extremely rare disease. Only a few cases on the surgical treatment of PMSNN have been reported in the literature, and it is unclear whether there is invasion of important peripancreatic vessels.
Patient Concerns: We report the case of a 39-year-old female patient with PMSNN accompanied by invasion of important peripancreatic vessels.