Exploring students' study time, sleep duration, and perceptions of course difficulty on final examination results: A cross-sectional study.

Objective: To evaluate the possible association between student final exam scores and student-reported measures of study time, sleep duration, perception of course difficulty, and grade satisfaction.

Methods: A 4-item questionnaire was administered to 354 3rd-quarter students during finals week. Students were asked to report their study time, sleep duration the night prior to the exam, and perception of course difficulty as well as grade satisfaction using a 5-point Likert scale response prior to taking the exam.

Effect of unproctored versus proctored examinations on student performance and long-term retention of knowledge.

Objective: To compare unproctored and proctored online exams among chiropractic students.

Methods: Pre-existing data of 234 students across 4 consecutive endocrinology classes were analyzed for this study. The course was comprised of 3 lectures (50 minutes per lecture) each week.

Comparison of mistakes on multiple-choice question and fill-in-the-blank examinations: A retrospective analysis.

Objective: The objective was to compare the average number of mistakes made on multiple-choice (MCQ) and fill-in-the-blank (FIB) questions in anatomy lab exams.

Methods: The study was conducted retrospectively; every exam had both MCQs and FIBs. The study cohorts were divided into 3 tiers based on the number and percentage of mistakes in answering sheets: low (21-32, >40%), middle (11-20, 40%-20%), and high (1-9, <20%) tiers.

Bio-Inspired Photoelectric Dual-Mode Sensor Based on Photonic Crystals for Human Motion Sensing and Monitoring.

Photoelectric dual-mode sensors, which respond to strain signal through photoelectric dual-signals, hold great promise as wearable sensors in human motion monitoring. In this work, a photoelectric dual-mode sensor based on photonic crystals hydrogel was developed for human joint motion detection. The optical signal of the sensor originated from the structural color of photonic crystals, which was achieved by tuning the polymethyl methacrylate (PMMA) microspheres diameter.

Naked-Eye Visual Thermometer Based on Glycerol─Nonclose-Packed Photonic Crystals for Real-Time Temperature Sensing and Monitoring.

Real-time sensing and monitoring of temperature are of great significance for assessing human health. The sensitivity and stability are inevitable issues for thermometers. In this study, a thermometer with the cylindrical thermochromic hydrogel was prepared for real-time visual monitoring of temperature, which had excellent temperature sensitivity, angle-independence axially, and environmental stability.

Polycationic Open-Shell Cyclophanes: Synthesis of Electron-Rich Chiral Macrocycles, and Redox-Dependent Electronic States.

π-Conjugated chiral nanorings with intriguing electronic structures and chiroptical properties have attracted considerable interests in synthetic chemistry and materials science. We present the design principles to access new chiral macrocycles (1 and 2) that are essentially built on the key components of main-group electron-donating carbazolyl moieties or the π-expanded aza[7]helicenes. Both macrocycles show the unique molecular conformations with a (quasi) figure-of-eight topology as a result of the conjugation patterns of 2,2',7,7'-spirobifluorenyl in 1 and triarylamine-coupled aza[7]helicene-based building blocks in 2.

Synthesis of π-Conjugated Chiral Aza/Boracyclophanes with a meta and para Substitution.

We herein describe the synthesis of a new class of axially chiral aza/boracyclophanes (BDN1, BXN1, BDB1 and BXB1) using binaphthyls as chiral building blocks and the main-group (B/N) chemistry with tunable electronic effects. All macrocycles substituted with triarylamine donors or triarylborane acceptors are strongly luminescent. These macrocycles showed two distinct meta and para π-conjugation pathways, leading to the formation of quasi figure-of-eight and square-shaped conformations.

Chiral Luminescent Aza[7]helicenes Functionalized with a Triarylborane Acceptor and Near-Infrared-Emissive Doublet-State Radicals.

This paper presents new chiral luminescent molecules ( and ) using configurationally stable aza[7]helicene () as a universal heteroatom-doped chiral scaffold. The respective reactions of electron-donating with a triarylborane acceptor via palladium-catalyzed Buchwald-Hartwig C-N coupling and with the open-shell doublet-state TTM radical via nucleophilic aromatic substitution (S2Ar) resulted not only in tunable emissions from blue to the NIR domain but also in significantly enhanced emission quantum efficiency up to Φ = 50%.

Identification of a Cryptic Binding Site in CRISPR-Cas9 for Targeted Inhibition.

The need for precision control of CRISPR-Cas9 genome editing has created a demand for anti-CRISPR molecules. Recently, the first class of small-molecule Cas9 inhibitors has been identified, verifying the feasibility of regulating CRISPR-Cas9 activity using direct-acting small molecules. However, it remains enigmatic as to the location of the ligand binding site(s) on CRISPR-Cas9 and how the ligand binding leads to Cas9 functional inhibition.

Synthesis of π-Conjugated Chiral Organoborane Macrocycles with Blue to Near-Infrared Emissions and the Diradical Character of Cations.

Highly emissive π-conjugated macrocycles with tunable circularly polarized luminescence (CPL) have sparked theoretical and synthetic interests in recent years. Herein, we report a synthetic approach to obtain new chiral organoborane macrocycles (, , and ) that are built on the structurally chiral [5]helicenes and highly luminescent triarylborane/amine moieties embedded into the cyclic systems. These rarely accessible B/N-doped main-group chiral macrocycles show a unique topology dependence of the optoelectronic and chiroptical properties.

Anlotinib combined with osimertinib reverses acquired osimertinib resistance in NSCLC by targeting the c-MET/MYC/AXL axis.

Favorable clinical evidence suggests that the next trend in new treatments for advanced non-small cell lung cancer (NSCLC) will be combination therapies. However, inevitable epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance greatly limits the clinical efficacy of patients carrying EGFR-activating mutants. In this study, we found a patient with clinical osimertinib resistance who regained a positive response after osimertinib plus anlotinib treatment.

The pseudogene DUXAP10 contributes to gefitinib resistance in NSCLC by repressing OAS2 expression.

Gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI),is the currently recommended first-line therapy for advanced EGFR-mutant lung cancer, and understanding the mechanism of resistance is the key to formulating therapeutic strategies for EGFR-TKIs. In this study, we evaluate the expression patterns and potential biological functions of the pseudogene DUXAP10 in gefitinib resistance. We find that pseudogene DUXAP10 expression is significantly upregulated in NSCLC gefitinib-resistant cells and tissues.

Expanding new chemistry of aza-boracyclophanes with unique dipolar structures, AIE and redox-active open-shell characteristics.

π-Conjugated macrocycles involving electron-deficient boron species have received increasing attention due to their intriguing tunable optoelectronic properties. However, most of the reported B(sp)-doped macrocycles are difficult to modify due to the synthetic challenge, which limits their further applications. Motivated by the research of non-strained hexameric bora- and aza-cyclophanes, we describe a new class of analogues MC-BN5 and MC-ABN5 that contain charge-reversed triarylborane (ArB) units and oligomeric triarylamines (ArN) in the cyclics.

Long noncoding RNA SNHG17: a novel molecule in human cancers.

Many studies in recent years have found that dysregulation of long non-coding RNAs (lncRNAs) can contribute to disease. Small nucleolar RNA host gene 17 (SNHG17) is a novel cancer-related lncRNA of the SNHG family which is highly expressed in various tumors and may exert oncogenic functions. Several studies have demonstrated that SNHG17 is closely related to the proliferation, migration, invasion, apoptosis, and chemical drug resistance of tumor cells, and clinical studies have found an association between high SNHG17 expression and poor prognosis.

Pillar[5]arene-based Neutral Radicals with Doublet Red Emissions and Stable Chiroptical Properties.

Stable organic radicals with unique luminescence show great importance in photoelectromagnetic materials. We herein report two unusual radical-based systems ( and ) using the concerted effects of planar chiral pillar[5]arenes and tris(2,4,6-trichlorophenyl)methyl () radicals. The steric effect and electronic doublet-spin character of these radicals allowed the optical resolution and the first red emissions (∼650 nm) for pillar[5]arene derivatives.

Oligotriarylamine-Extended Organoboranes with Tunable Electron-Donating Strength by Changing the Number of Donor Units.

Triarylborane (ArB) and triarylamine (ArN) have been widely employed to construct electronically different donor-acceptor (D-A) systems. Herein, we describe a series of A-D-A-type luminescent organoboranes ( = 1, 3, 5) that show an increased number of ArN units as electron donors and two terminal ArB as acceptors. When the ArN moieties were extended from one to five units, their electron-donating strength was gradually enhanced and the highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) energy gaps could also be tuned, which was further reflected in the red-shifted emissions from blue (λ = 458 nm) to orange (λ = 595 nm) with a decrease in from 3.

A comparison of virtual and in-person instruction in a physical examination course during the COVID-19 pandemic.

Objective: To compare virtual and in-person physical examination (PE) learning among chiropractic students.

Methods: Preexisting assessment data from 69 students enrolled in a Head and Neck PE course were analyzed for this study. The course comprised three 50-minute labs and one 50-minute lecture each week.

Pillar[5]arene-Based Dual Chiral Organoboranes with Allowed Host-Guest Chemistry and Circularly Polarized Luminescence.

We first describe two examples of highly luminescent organoboranes ( and ) with dual chirality that were achieved by molecular functionalization of planar chiral pillar[5]arenes with naphthyls. Sufficiently strong steric effects are imposed by triarylamine (ArN) and triarylborane (ArB) moieties and further enhanced by the proximity of the chiral building blocks, leading to the isolation of multiple enantiomers via chiral high-performance liquid chromatography. The intramolecular charge transfer from N-donor to B-acceptor across both chiral subunits enabled the circularly polarized luminescence and thermally robust colorimetric responses in their emissions.

Access to Highly Luminescent N-Doped Diazaborepins with Penta-, Hexa-, and Heptagon Substructures.

Two diazaborepins ( and ) have been accomplished via a highly efficient pathway in the step-economic transformation. Oxidative dimerization of carbazole derivatives followed by borylation reaction gave heterocyclic diazaborepin as the key building block. Replacement of carbon moiety in traditional borepins with N-N functionality led to a significant red shift of their emissions up to 585 nm with strong red color as solids.