Immune and non-immune cell subtypes identify novel targets for prognostic and therapeutic strategy: A study based on intratumoral heterogenicity analysis of multicenter scRNA-seq datasets in lung adenocarcinoma.

Lung adenocarcinoma (LUAD) is the most common type of lung cancer and the leading cause of cancer incidence and mortality worldwide. Despite the improvement of traditional and immunological therapies, the clinical outcome of LUAD is still far from satisfactory. Patients given the same treatment regimen had different responses and clinical outcomes due to the heterogeneity of LUAD.

Occupational stress and associated risk factors among 13,867 industrial workers in China.

Objective: Occupational stress is a critical global public health problem. We aimed to evaluate the prevalence of occupational stress among the workers in the electricity, heat, gas, water production and supply (EHGWPS), manufacturing, and transportation industries in Beijing, China. We explored the demographic differences in occupational stress status among workers in industrial enterprises.

Lexicon and attention-based named entity recognition for kiwifruit diseases and pests: A Deep learning approach.

Named Entity Recognition (NER) is a crucial step in mining information from massive agricultural texts, which is required in the construction of many knowledge-based agricultural support systems, such as agricultural technology question answering systems. The vital domain characteristics of Chinese agricultural text cause the Chinese NER (CNER) in kiwifruit diseases and pests to suffer from the insensitivity of common word segmentation tools to kiwifruit-related texts and the feature extraction capability of the sequence encoding layer being challenged. In order to alleviate the above problems, effectively mine information from kiwifruit-related texts to provide support for agricultural support systems such as agricultural question answering systems, this study constructed a novel Chinese agricultural NER (CANER) model KIWINER by statistics-based new word detection and two novel modules, AttSoftlexicon (Criss-cross attention-based Softlexicon) and PCAT (Parallel connection criss-cross attention), proposed in this paper.

Phosphorylation-Driven Production of d-Allulose from d-Glucose by Coupling with an ATP Regeneration System.

d-Allulose is a desirable sucrose substitute with potential applications in food and health care. d-Allulose can be synthesized using d-glucose as a substrate through coupling glucose isomerase with d-allulose 3-epimerase (DAEase); however, the product yield is typically less than 20% at reaction equilibrium and thus limits its use in industrial applications. Here, a 3R-ketose phosphorylation pathway coupled with an adenosine triphosphate (ATP) regeneration system was developed for the efficient synthesis of d-allulose in using d-glucose as a substrate.

Ophthalmic characteristics and retinal vasculature changes in Williams syndrome, and its association with systemic diseases.

Background: We aim to characterise the ophthalmic findings and retinal vasculature changes in patients with WS, and to analyse the correlation between ophthalmic manifestations and the associated systemic diseases.

Methods: This retrospective case-control study included 27 WS patients and 28 age-matched healthy participants. Stellate pattern of iris, central macular thickness (CMT), foveal width, retinal vessel diameter, superficial vascular density (SVD) of macula and foveal avascular zone (FAZ) were compared between WS patients and healthy participants.

Analysis of Landscape Characteristics and Influencing Factors of Residential Areas on the Qinghai-Tibet Plateau: A Case Study of Tibet, China.

The Qinghai-Tibet Plateau is the largest ecological barrier and one of the most vulnerable areas of the ecological environmental system. However, the increasing frequency of human activities in the Qinghai-Tibet Plateau has led to strong interference. Residential areas are the main places in which human activities are carried out and, as such, can effectively reflect the intensity of activities.

Purification of Camellia Oil by Inorganic Ceramic Membrane.

Camellia oil is an edible health oil with high medicinal value. While phospholipids, peroxides, and free fatty acids are present in unrefined camellia virgin oil (CVO), which has a negative impact on the quality characteristics and storage stability. This paper is to investigate the testing effects of transmembrane pressure and temperature on the membrane flux and degumming (the removal of colloidal substances from crude oil and which is mainly phospholipids) to determine the optimum process parameters for the purification of CVO.

S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression.

Pulmonary fibrosis (PF) is a chronic lung disease characterised by alveolar inflammatory injury, alveolar septal thickening, and eventually fibrosis. Patients with severe Coronavirus Disease 2019 (COVID-19) may have left a certain degree of pulmonary fibrosis. PF is commonly caused by oxidative imbalance and inflammatory damage.

Potential applications of pulsed electric field in the fermented wine industry.

Fermented wine refers to alcoholic beverages with complex flavor substances directly produced by raw materials (fruit or rice) through microbial fermentation (yeast and bacteria). Its production steps usually include saccharification, fermentation, filtration, sterilization, aging, etc., which is a complicated and time-consuming process.

Highly-efficient molten NaOH-KOH for organochlorine destruction: Performance and mechanism.

Molten salt has been increasingly acknowledged to be useful in the destruction of chlorine-containing organic wastes (COWs), e.g., organochlorine.

Global, regional, and national years lived with disability due to blindness and vision loss from 1990 to 2019: Findings from the Global Burden of Disease Study 2019.

Purpose: This study aimed to provide a comprehensive assessment of burden estimates and the secular trend of blindness and vision loss, as measured by years lived with disability (YLDs), at the global, regional, and national levels.

Methods: The age-standardized YLD rates (ASYRs) due to blindness and vision loss and its subtypes, including moderate vision loss, severe vision loss, blindness, and presbyopia, from 1990 to 2019 were extracted from the Global Burden of Disease Study 2019 database. The estimated annual percentage changes (EAPCs) were calculated to quantify the temporal trends in the ASYRs due to blindness and vision loss.

Occupancy-aided ventilation for airborne infection risk control: Continuously or intermittently reduced occupancies?

Ventilation is an important engineering measure to control the airborne infection risk of acute respiratory diseases, e.g., Corona Virus Disease 2019 (COVID-19).

An International Comparative Study on the Resilience of Urban Communities after COVID-19 Pandemic: A One-Year Case Study between Lanzhou, China and Sarajevo, Bosnia and Herzegovina.

After the prevailing of the COVID-19 pandemic, urban communities around the world took initiatives to bring their cities back to life. In this research, 45 indicators and 55 elements were selected to make comparisons between urban communities in Lanzhou, China and Sarajevo, Bosnia and Herzegovina from five dimensions of social resilience, economic resilience, institutional resilience, infrastructural resilience, and community capital resilience. At the same time, the ArcGIS platform tool was used for spatial interpolation analysis.

Physical activity (PA) influences the risk of depression associated with long working hours.

Background: Growing evidences showed that long working hours is associated with depression epidemic, but few studies investigate whether physical activity (PA) could modify the risk of depression associated with long working hours, which was the purpose of the present study.

Methods: A cross-sectional data obtained from the National Health and Nutrition Examination Survey 2015-2018. According to the criteria of International Labour Organization, long working hours was defined as >40 h/wk.

Advances in experimental models of rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent articular inflammation and joint damage. RA was first described over 200 years ago; however, its etiology and pathophysiology remain insufficiently understood. The current treatment of RA is mainly empirical or based on the current understanding of etiology with limited efficacy and/or substantial side effects.

Ensiling Improved the Colonization and Degradation Ability of in Wheat Straw.

To develop a non-thermal method to replace steam autoclaving for white-rot fungi fermentation, spawn was inoculated in wheat straw (WSI) or ensiled WS (WSI) at varying ratios of 10%, 20%, 30%, 40%, and 50%, and incubated at 28 °C for 28 days to determine the effects of the ensiling and inoculation ratio on the colonization and degradation ability of in wheat straw (WS). The results demonstrate that ensiling effectively inhibited the growth of aerobic bacteria and molds, as well as other harmful microorganisms in WS, which created a favorable condition for the growth of . After the treatment of , the pH of EWSI decreased to below 5, while that of WSI, except for the feedstocks of WSI-50%, was around 7, indicating that colonized well in the ensiled WS because the substrates dominated by are generally acidic.

Acute and chronic viruses mediated by an ectoparasite targeting different developmental stages of honeybee ( and ) brood.

The health of the western honeybee, , the most crucial pollinator, has been challenged globally over the past decades. An ectoparasitic mite, , together with the viruses it vectored, is generally regarded as the vital pathogenic agent. Although the poor health status of compared to its eastern counterpart, , has been broadly identified, the underlying mechanism remains poorly understood and comparison between susceptible and resistant hosts will potentially ameliorate this predicament.

Comparative transcriptomics reveal different genetic adaptations of biofilm formation in isolate 1JN2 in response to Cd treatment.

Biofilm plays important roles in the life cycle of species, such as promoting host and object surface colonization and resisting heavy metal stress. This study utilized transcriptomics to evaluate the impacts of cadmium on the components, morphology, and function of biofilms of strain 1JN2. Under cadmium ion stress, the morphology of the 1JN2 biofilm was flattened, and its mobility increased.

CRM197-conjugated multi antigen dominant epitope for effective human cytomegalovirus vaccine development.

Human cytomegalovirus (HCMV) infection is a major cause of neonatal neurodevelopmental disorders and serious complications in organ transplantation. Previous HCMV vaccines focused on humoral immunity but had limited effect on viral infection. T-cell responses are essential to prevent HCMV infection, indicating that effective vaccines require T cells activation.

Mechanobiology Platform Realized Using Photomechanical Mxene Nanocomposites: Bilayer Photoactuator Design and In Vitro Mechanical Forces Stimulation.

Mechanotransduction is the process by which cells convert external forces and physical constraints into biochemical signals that control several aspects of cellular behavior. A number of approaches have been proposed to investigate the mechanisms of mechanotransduction; however, it remains a great challenge to develop a platform for dynamic multivariate mechanical stimulation of single cells and small colonies of cells. In this study, we combined polydimethylsiloxane (PDMS) and PDMS/Mxene nanoplatelets (MNPs) to construct a soft bilayer nanocomposite for extracellular mechanical stimulation.

Polypharmacology-based approach for screening TCM against coinfection of and .

Natural products and their unique polypharmacology offer significant advantages for finding novel therapeutics particularly for the treatment of complex diseases. Meanwhile, Traditional Chinese Medicine exerts overall clinical benefits through a multi-component and multi-target approach. In this study, we used the previously established co-infection model of and as a representative of complex diseases.

Kurstakin Triggers Multicellular Behaviors in AR156 and Enhances Disease Control Efficacy Against Rice Sheath Blight.

Kurstakin is the latest discovered family of lipopeptides secreted by spp. In this study, the effects of kurstakin on the direct antagonism, multicellularity, and disease control ability of AR156 were explored. An insertion mutation in the nonribosomal peptide synthase responsible for kurstakin synthesis led to a significant reduction of antagonistic ability of AR156 against the plant-pathogenic fungi , , , and f.

Association of Red Cell Distribution Width-to-Platelet Ratio and Mortality in Patients with Sepsis.

Background: As a novel inflammatory index, the ratio of red cell distribution width (RDW) to platelet count (RPR) may have prognostic value in some critical illnesses. However, studies on the prognostic influence of RPR in patients with sepsis are few. This study is aimed at investigating the association between RPR levels and 28-day mortality in patients with sepsis.