Deep learning model targeting cancer surrounding tissues for accurate cancer diagnosis based on histopathological images.

Accurate and fast histological diagnosis of cancers is crucial for successful treatment. The deep learning-based approaches have assisted pathologists in efficient cancer diagnosis. The remodeled microenvironment and field cancerization may enable the cancer-specific features in the image of non-cancer regions surrounding cancer, which may provide additional information not available in the cancer region to improve cancer diagnosis.

Cobalt-Catalyzed Hydroglycosylation of Alkynes for the Synthesis of Vinyl α-C-Glycosides.

Herein we report a cobalt-catalyzed hydroglycosylation of terminal alkynes, employing bench-stable ortho-iodobiphenyl (oIB) substituted sulfides as glycosyl donors. This reaction occurs with high stereo- and regioselectivity to afford E-configured vinyl α-C-glycosides, a class of compounds nontrivial to access by previous methods. The use of a bis(oxazoline) ligand with bulky side chains is critical for the high selectivities observed.

Simultaneous Toughening and Strengthening of Ductile Polymer by Rigid Polymeric Fillers: The Role of Interfacial Entanglement.

The modification of thermoplastic polymers is frequently impeded by the inherent contradiction between their toughness and strength. In this study, an effective strategy to significantly improve the mechanical properties of ductile polymers by simply adding a complimentary rigid polymer is introduced. This work uses a semi-crystalline polymer aliphatic polyketone (POK) as the matrix material and a small quantity of polymethyl methacrylate (PMMA) as the rigid polymer, through establishing molecular chain entanglements at the interface to produce POK/PMMA blends with exceptional mechanical property.

Mechanical and Ecological Properties of CO Curing Magnesium Slag Concrete.

Magnesium slag is a by-product of the magnesium industry. As an auxiliary cementitious material incorporated into concrete, it can make full use of waste resources and has a certain potential for hydration and carbonation. To improve the mechanical properties of the concrete, the influence mechanism and strengthening mechanism of the carbon curing method on mechanical properties of magnesium slag concrete were investigated.

Natural starches suitable for 3D printing: Rhizome and seed starch from Millettia speciosa champ, a non-conventional source.

The demand for exploring and investigating novel starches for various applications has been high, yet starches abundant in Millettia speciosa Champ (M. speciose) plants have barely been studied. This study aims to investigate the multiscale structure and physicochemical properties, especially good hot-extrusion 3D printability of M.

Rewriting Viral Fate: Epigenetic and Transcriptional Dynamics in KSHV Infection.

Kaposi's sarcoma-associated herpesvirus (KSHV), a γ-herpesvirus, is predominantly associated with Kaposi's sarcoma (KS) as well as two lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). Like other herpesviruses, KSHV employs two distinct life cycles: latency and lytic replication. To establish a lifelong persistent infection, KSHV has evolved various strategies to manipulate the epigenetic machinery of the host.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Role of programmed cell death in mammalian ovarian follicular atresia.

Programmed cell death (PCD) is a fundamental process in the development process of organisms, including apoptosis, autophagy, ferroptosis, and pyroptosis. In mammalian ovaries, 99 % of follicles undergo atresia, while only 1 % mature and ovulate, which limits the reproductive efficiency of mammals. The PCD process is closely related to the regulation of follicle development and atresia.

Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2.

Ethnopharmacological Relevance: Chronic fatigue syndrome (CFS), as a complex, multisystemic, and multisystemic disorder affecting multiple organs and systems, often accompanies by symptoms such as post-exercise discomfort, sleep disorders, cognitive difficulties, and orthostatic intolerance. Jingfang Granule (JFG) is a traditional Chinese medicine that have significant protective effects on CFS, but the mechanism is still vague.

Aim Of Study: This study was designed to evaluate the protective mechanism of JFG on mice with CFS.

Magnetic nanoparticle-mediated non-invasive imaging and eradication of lymph nodes.

Regional lymph node (LN) dissection is often used for the treatment of deep LNs in tumour surgery; however, the method is prone to incomplete LN dissection, trauma, complications, and other side effects. LN tracers make it easier to visualise and remove LNs. However, the current common LN tracers only have a single function or have radiation hazards related to their use.

Vitamin D supplementation may be beneficial in improving the prognosis of patients with sepsis-associated acute kidney injury in the intensive care unit: a retrospective study.

Background: Vitamin D, an essential fat-soluble micronutrient, exerts diverse physiological effects including the regulation of calcium ion homeostasis, modulation of immune response, and enhancement of resistance against infectious pathogens. Empirical investigations have elucidated an association between inadequate levels of vitamin D and adverse clinical outcomes in critically ill cohorts, with a noteworthy prevalence of vitamin D deficiency observed among patients afflicted with acute kidney injury (AKI). In the context of this retrospective inquiry, our aim was to assess the potential correlation between vitamin D supplementation administered during admission to the intensive care unit (ICU) and the improvement of outcomes specifically in cases of severe AKI.

Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.

Ovarian dysfunction caused by aging restricts female reproductive capacity and is accompanied by oxidative stress and impaired autophagy. Recent studies have shown that trehalose (Tre) can activate autophagy and have antioxidant effects. However, whether Tre can be used to attenuate ovarian aging remains unclear.

Organoclay flocculation as a pathway to export carbon from the sea surface.

Marine microorganisms play a critical role in regulating atmospheric CO concentration via the biological carbon pump. Deposition of continental mineral dust on the sea surface increases carbon sequestration but the interaction between minerals and marine microorganisms is not well understood. We discovered that the interaction of clay minerals with dissolved organic matter and a γ-proteobacterium in seawater increases Transparent Exopolymer Particle (TEP) concentration, leading to organoclay floc formation.

[Characteristics and Sources of Volatile Organic Compounds （VOCs） in Luohe City During Summer].

Luohe City is an important node city in the Central Plains Urban Agglomeration in China, where the atmospheric ozone （O） pollution situation has been serious in recent years. In order to provide a scientific basis for O pollution control, the online filed observation of O precursor volatile organic compounds （VOCs） was carried out in Luohe City in July 2022 to understand their variation characteristics and sources. The mean ratio of （TVOCs） during the observation period was （16.

Insights into Dual Self-Assembly Mechanisms in Various (Parkinson) Fosberg Starch-Endogenous Lipid-Endogenous Protein Complexes: Interactions between Digestibility Kinetics and Multiscale Structure.

Chinese seedless breadfruit is rich in starch, lipids, and protein. To explore the interactions among these macromolecules during food processing, the seedless breadfruit starch-endogenous lipid-endogenous protein complex was investigated. Native seedless breadfruit starches are categorized as low-resistant-content starch [low-resistant starch (LRS)] or high-resistant starch (HRS).

Physiological and Molecular Mechanisms of Lepidopteran Insects: Genomic Insights and Applications of Genome Editing for Future Research.

Lepidopteran insects are a major threat to global agriculture, causing significant crop losses and economic damage. Traditional pest control methods are becoming less effective due to the rapid evolution of insecticide resistance. This study explores the current status and genomic characteristics of 1315 Lepidopteran records, alongside an overview of relevant research, utilizing advanced functional genomics techniques, including RNA-seq and CRISPR/Cas9 gene-editing technologies to uncover the molecular mechanisms underlying insecticide resistance.

Enhancing β-Galactosidase Performance for Galactooligosaccharides Preparation via Strategic Glucose Re-Tunneling.

This study focuses on the characterization and re-engineering of glucose transport in β-galactosidase (BglD) to enhance its catalytic efficiency. Computational prediction methods were employed to identify key residues constituting access tunnels for lactose and glucose, revealing distinct pockets for both substrates. In silico simulated saturation mutagenesis of residues T215 and T473 led to the identification of eight mutant variants exhibiting potential enhancements in glucose transport.

Revealing the synergistic antibacterial mechanisms of resveratrol (RES) and pulsed electric field (PEF) against Acetobacter sp.

In the wine industry, Acetobacter sp. is a typical spoilage microorganism responsible for increased volatile acids and wine spoilage. This study investigated the impact of combined treatment using varying concentrations of resveratrol (RES) and pulsed electric field (PEF) on the bactericidal efficacy, intracellular enzyme activities, and cellular metabolism of Acetobacter sp.

Effect of fermentation temperature on the non-volatile components and hypoglycemic activity of Jinxuan black tea.

Fermentation significantly influences the chemical composition of black tea, yet the effects of different fermentation temperatures on non-volatile components and their hypoglycemic activity are insufficiently studied. This research investigates how varying temperatures (20, 25, and 30°C) affect the bioactive profile and the inhibitory activity of Jinxuan black tea against α-glucosidase and α-amylase. Our results show that lower fermentation temperatures (20°C) lead to elevated levels of key bioactive compounds, including tea polyphenols (9.

Polyvinyl alcohol/sodium alginate hydrogels with tunable mechanical and conductive properties for flexible sensing applications.

Despite the significant advantages of conductive hydrogels in flexible sensing, their further development is often hindered by limitations in strength and conductivity. In this work, the ionic conductive hydrogels with tunable mechanical and conductive properties were designed by utilizing sodium alginate (SA) to reinforce the polyvinyl alcohol (PVA) networks, followed by the respective introduction of LiSO, ZnSO, and Fe(SO), leveraging the Hofmeister effect and metal coordination. Consequently, the mechanical properties (σ = 0.

SUMOylation of AL6 regulates seed dormancy and thermoinhibition in Arabidopsis.

DELAY OF GERMINATION1 (DOG1) is a critical regulator of seed dormancy and seed thermoinhibition. However, how DOG1 expression is regulated by post-translational modifications and how seeds transmit the high-temperature signal to DOG1 remain largely unknown. ALFIN1-like 6/7 (AL6/7) was previously found to repress DOG1 expression during seed imbibition.