Publications by authors named "Nitzan Burrack"
Article Synopsis
- Income-based disparities in hip fracture treatment and outcomes were examined across six high-income countries, revealing that lower-income individuals generally faced worse health outcomes.
- The study indicated that low-income populations had higher incidence rates of hip fractures and worse 1-year mortality compared to their high-income counterparts, with the most pronounced difference in Israel.
- Overall, high-income patients experienced shorter hospital stays, lower readmission rates, and quicker surgery times, highlighting the significant impact of income on healthcare quality and access for older adults with hip fractures.
Background: The best first-line monotherapy for hypertension remains uncertain, as current guidelines suggest that thiazides, angiotensin-converting enzyme inhibitors (ACEis), angiotensin receptor blockers (ARBs), and calcium channel blockers (CCBs) are appropriate in the absence of specific comorbidities. We aimed to compare the outcomes of first-line antihypertensive classes in a real-life setting with a long follow-up period.
Methods: This nationwide retrospective new-user cohort study included patients insured by the largest health maintenance organization in Israel.
Background: Respiratory syncytial virus (RSV) is a significant cause of illness in adults, especially older adults and those with underlying conditions. This study aimed to assess the incidence of RSV hospitalizations in adults and identify risk factors for hospitalization and poor outcomes.
Methods: A retrospective cohort study was conducted using data from two hospitals in southern Israel from 2016-2022.
Schizophrenia symptomatology includes negative symptoms and cognitive impairment. Several studies have linked schizophrenia with the PDE4 family of enzymes due to their genetic association and function in cognitive processes such as long-term potentiation. We conducted a systematic gene expression meta-analysis of four PDE4 genes (PDE4A-D) in 10 brain sample datasets (437 samples) and three blood sample datasets (300 samples).
View Article and Find Full Text PDFArticle Synopsis
- Chronic spontaneous urticaria (CSU) is a skin condition that can significantly impact a person's quality of life, and markers of inflammation like neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios could be helpful in evaluating it.
- A study analyzed data from over 13,500 patients diagnosed with urticaria to explore these inflammatory markers in different patient groups, including acute versus chronic cases and varying severities.
- The findings indicated that CSU patients had higher inflammatory marker levels compared to those with acute urticaria, and higher levels correlated with more severe cases, suggesting these markers could help predict the severity and chronicity of urticaria.
Article Synopsis
- Acute bronchiolitis is a leading cause of hospitalization in infants globally, and this study examines the relationship between an infant's weight and the severity of RSV bronchiolitis.
- A retrospective analysis of 1,936 infants revealed that underweight infants experienced higher rates of PICU admissions (9.1%) and longer hospital stays (3.13 days) than normal-weight infants (3.5% and 2.79 days).
- The findings indicate that underweight infants are at a greater risk for severe disease complications, suggesting the need for closer monitoring of this vulnerable group.
Article Synopsis
- Hematological markers like eosinophil-to-lymphocyte (ELR), eosinophil-to-neutrophil (ENR), and eosinophil-to-monocyte (EMR) ratios could help assess skin diseases, but their specific connection to vitiligo was uncertain.
- This study analyzed these markers in nearly 10,000 vitiligo patients and found that children had higher ratios than adults, and those with severe vitiligo exhibited even higher levels compared to mild cases.
- Elevated ENR and EMR ratios were associated with a significantly increased risk of developing severe vitiligo up to 18 months before diagnosis, suggesting these markers could aid in the prognosis of the condition.
Article Synopsis
- The study examined how older men and women are treated for heart attacks (STEMI and NSTEMI) in six countries, focusing on hospitalization rates, intervention procedures, and outcomes from 2011 to 2018.
- Results showed that while hospitalization rates for heart attacks fell across all countries, the rate ratio of male to female hospitalizations rose, indicating a growing disparity.
- Females consistently received fewer interventional procedures than males for STEMI across the board, and mortality rates differed, with females often faring worse in STEMI outcomes in most countries but better in NSTEMI outcomes in others.
Background And Aims: Amiodarone-related interstitial lung disease (ILD) is the most severe adverse effect of amiodarone treatment. Most data on amiodarone-related ILD are derived from periods when amiodarone was given at higher doses than currently used.
Methods: A nationwide population-based study was conducted among patients with incident atrial fibrillation (AF) between 1 December 1999 and 31 December 31 2021.
Objective: Acute bronchiolitis is the most common cause of hospitalization in young children. Data on monocyte-to-lymphocyte-ratio (MLR) and neutrophil-to-lymphocyte-ratio (NLR) as biomarkers are limited. We aim to evaluate these ratios in children hospitalized with respiratory syncytial virus (RSV) bronchiolitis and their value as biomarkers for severe clinical outcomes.
View Article and Find Full Text PDFBackground: Hip fractures are costly and common in older adults, but there is limited understanding of how treatment patterns and outcomes might differ between countries.
Methods: We performed a retrospective serial cross-sectional cohort study of adults aged ≥66 years hospitalized with hip fracture between 2011 and 2018 in the US, Canada, England, the Netherlands, Taiwan, and Israel using population-representative administrative data. We examined mortality, hip fracture treatment approaches (total hip arthroplasty [THA], hemiarthroplasty [HA], internal fixation [IF], and nonoperative), and health system performance measures, including hospital length of stay (LOS), 30-day readmission rates, and time-to-surgery.