Publications by authors named "Nitza Vara"
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal (GI) tract with dysregulated mucosal immune functions and disturbed commensal ecosystem of the intestinal lumen. IBD is categorized into two major subsets: Crohn's disease (CD) and ulcerative colitis (UC). Though advent of biologics has shifted the treatment with relatively longer remission compared to small molecule pharmaceuticals, patients still suffer from long-term complications.
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- - The study uses a dual-age-specific mouse model to investigate how disrupted age-specific hematopoiesis might relate to leukemia, showing that loss of Pten during the transition from fetal to adult hematopoiesis can lead to juvenile leukemia and not contribute positively in the same age group.
- - It was found that juvenile mice display myeloid-biased hematopoiesis, linked to properties of fetal hematopoietic stem cells (HSCs), and that the development of juvenile myelomonocytic leukemia is influenced by the amounts of Pten and Nf1 genes present.
- - The research suggests that having just one copy of Pten is sufficient to keep the HSC function stable, despite activation of