FLT3-ITD Mutations in Acute Myeloid Leukemia Patients in Northeast Thailand.

The FLT3-ITD mutation is one of the most frequent genetic abnormalities in acute myeloid leukemia (AML) where it is associated with a poor prognosis. The FLT3-ITD mutation could, therefore, be a potential molecular prognostic marker important for risk-stratified treatment options. We amplified the FLT3 gene at exon 14 and 15 in 52 AML patients (aged between 2 months and 74 years) from 4 referral centers (a university hospital and 3 regional hospitals in Northeast Thailand), using a simple PCR method.

Impaired glucose tolerance and insulin resistance in survivors of childhood acute lymphoblastic leukemia: prevalence and risk factors.

Aim/purpose: Survivors of acute lymphoblastic leukemia (ALL) are at increased risks of impaired glucose metabolism, insulin resistance, and metabolic syndrome. The aim of our study was to determine the prevalence of alterations in glucose metabolism and the predisposing factors of these disturbances in survivors of childhood ALL.

Patients And Methods: In 131 ALL survivors, an oral glucose tolerance test was conducted to determine beta-cell function/insulin sensitivity.

Thalassemic mothers and their babies.

Thirty-two mothers with thalassemia, more than half of whom had hemoglobin H disease with or without other forms of thalassemia or hemoglobinopathies along with their 46 children were evaluated. The mean maternal hematocrit was 22.2% and the mean maternal body mass index was 18.