Preparation and characterization of nanocapsules for colon-targeted drug delivery system.

Context: Nanoparticles for colon-specific drug delivery system are known for their specific accumulation in the inflamed tissue in the colon and may therefore allow a selective delivery to the site of inflammation for the treatment of inflammatory bowel disease (IBD).

Objective: The objective of this study was to formulate and evaluate nanocapsules (NC), an oral system designed to achieve site-specific and instant drug release in colon for effective treatment of IBD.

Materials And Methods: Prednisolone (PD), a typical glucocorticoid, has been widely used for the treatment of IBD.