Publications by authors named "Nitin S Argade"
Formulation and evaluation of transdermal patches of donepezil.
Recent Pat Drug Deliv Formul
January 2016
Article Synopsis
- The study focuses on developing transdermal patches for Donepezil, a drug used to treat Alzheimer's disease, aiming to improve patient compliance, efficacy, and minimize side effects by avoiding first-pass metabolism.
- Various polymers and formulations were tested, with the optimal patch using Eudragit S-100, Eudragit E-100, and HPMC, combined with glycerine showing promising physicochemical properties and a zero-order drug release profile.
- Results indicate that the transdermal patch can prolong Donepezil release for several hours, enhance its absorption into the bloodstream, and reduce initial drug breakdown in the liver.