Publications by authors named "Nitin Mahobia"
Article Synopsis
- There is a global rise in antimicrobial resistance (AMR) primarily attributed to the overuse and misuse of antibiotics, which poses challenges for healthcare and patient treatment, especially in urinary tract infections (UTIs) caused by gram-negative bacteria (GNB).
- A comprehensive analysis of over 650,000 urine cultures from a Southern England hospital over eight years revealed that Nitrofurantoin showed better effectiveness across all age groups compared to other antibiotics like ampicillin/amoxicillin and trimethoprim, which had poor resistance profiles.
- The study indicated that males and individuals over 60 are at a higher risk of developing AMR, necessitating tailored antibiotic use to improve treatment outcomes in various subpopulations.
Article Synopsis
- The study investigates antimicrobial resistance (AMR) patterns in urinary tract infections (UTIs) caused by Gram-negative bacteria, highlighting the issues arising from antibiotic overuse.
- Analyzing over 650,000 urine cultures from 2014 to 2022, researchers found low resistance rates to Amikacin, Gentamicin, and Co-Amoxiclav, but increasing resistance trends for other antibiotics like Cefalexin and Nitrofurantoin.
- Despite guidelines aimed at managing UTIs, resistance patterns are still evolving, prompting the need for healthcare providers to stay informed when prescribing antibiotics for UTIs and Gram-negative infections.
Introduction: Through routine respiratory samples surveillance among COVID-19 patients in the intensive care, three patients with aspergillus were identified in a newly opened general intensive care unit during the second wave of the pandemic.
Methodology: As no previous cases of aspergillus had occurred since the unit had opened. An urgent multidisciplinary outbreak meeting was held.
Article Synopsis
- The study examined how SARS-CoV-2 spreads via contact routes and its stability on surfaces, highlighting concerns about person-to-person and environment-to-person transmission.
- It tested for SARS-CoV-2 viral RNA on personal protective equipment (PPE), high-touch surfaces, and around the beds of COVID-19-positive patients.
- Results showed no viral RNA on PPE or most surfaces, but all samples from a room during aerosol-generating procedures tested positive, indicating higher contamination risk in those environments.
The provision of high-quality personal protective equipment (PPE) has been a critical challenge during the COVID-19 pandemic. We evaluated an alternative strategy, mass deployment of a powered air-purifying respirator (PeRSo), in a large university hospital. We performed prospective user feedback questionnaires sent to healthcare workers (HCWs) issued PeRSos, economic analysis, and evaluated the real-world impact.
View Article and Find Full Text PDFSARS-CoV-2 infection is a global pandemic. Personal Protective Equipment (PPE) to protect healthcare workers has been a recurrent challenge in terms of global stocks, supply logistics and suitability. In some settings, around 20% of healthcare workers treating COVID-19 cases have become infected, which leads to staff absence at peaks of the pandemic, and in some cases mortality.
View Article and Find Full Text PDFArticle Synopsis
- Antibiotic microbial resistance (AMR) is a global health issue, and the study focused on E.coli resistance to antibiotics at a university hospital over six years to evaluate changes in resistance patterns according to a standardized antibiotic policy.
- The research analyzed the sensitivity of E.coli urine isolates from 2014-2019, examining resistance trends for various antibiotics using statistical methods.
- Findings showed increased resistance for frequently used antibiotics like ciprofloxacin, co-amoxiclav, gentamicin, and tazocin, while resistance remained stable overall, prompting the hospital to continue reviewing its antibiotic usage protocols to combat AMR.
Background: We report an outbreak of SARS coronavirus-2 (SARS-CoV-2) infection among healthcare workers (HCW) in an NHS elective healthcare facility.
Methodology: A narrative chronological account of events after declaring an outbreak of SARS-CoV-2 among HCWs. As part of the investigations, HCWs were offered testing during the outbreak.
Antimicrobial resistance (AMR) has been identified by the World Health Organisation as a global threat that currently claims at least 25,000 deaths each year in Europe and 700,000 globally; the number is projected to reach 10 million per year between 2015 and 2050. Therefore, there is an urgent need for low-cost but reliable point-of-care diagnostics for early screening of infections especially in developing countries lacking in basic infrastructure and trained personnel. This work is aimed at developing such a device, a paper-based microfluidic device for infection testing by an unskilled user in a low resource setting.
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