The Mental Health Challenges of Medical Postgraduates in Chengalpattu District, Tamil Nadu: Are they being Educated or Exploited?

Introduction Globally, psychological morbidity among medical postgraduates (PGs) is an often overlooked and underreported condition. The study was done to find the prevalence of depression and stress among PGs and to find and explore the associated factors contributing to their stress and depression.  Methodology The study followed a convergent parallel mixed-method approach, in which qualitative and quantitative data were collected simultaneously.

A Cross-Sectional Study on the Prevalence of Skipping Breakfast Among College-Going Students in a Private University.

Background Breakfast is considered one of the important meals of the day as it repletes glucose supply to the brain and improves learning. Skipping breakfast has become more common among college students. It is prompting them to adopt unhealthy lifestyles which might affect their health in the long term.

Spectrum of [18F]FDG PET/CT Findings in Primary Central Nervous System Lymphoma - A Pictorial Essay.

Primary central nervous system lymphoma (PCNSL) is a rare, aggressive variant of extranodal non-Hodgkin's lymphoma. Although gadolinium-enhanced magnetic resonance imaging remains the initial imaging modality of choice, a whole-body F-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography is imperative to exclude systemic lymphomatous involvement. Furthermore, the metabolic parameter, maximum standardized uptake value (SUV) of the lesion, tumor-to-normal cerebral tissue SUV ratio, and FDG uptake patterns help in differentiating intracranial lymphomas from High-grade Glioblastoma Multiforme (HGM) and infectious lesions, and hence, consolidating the diagnosis.

Neurological, cardiac, musculoskeletal, and renal manifestations of scleroderma along with insights into its genetics, pathophysiology, diagnostic, and therapeutic updates.

Background: Scleroderma, also referred to as systemic sclerosis, is a multifaceted autoimmune condition characterized by abnormal fibrosis and impaired vascular function. Pathologically, it encompasses the persistent presence of inflammation, abnormal collagen buildup, and restructuring of blood vessels in various organs, resulting in a wide range of clinical symptoms. This review incorporates the most recent scientific literature on scleroderma, with a particular emphasis on its pathophysiology, clinical manifestations, diagnostic approaches, and treatment options.

An Early Detection and Classification of Alzheimer's Disease Framework Based on ResNet-50.

Objective: The objective of this study is to develop a more effective early detection system for Alzheimer's disease (AD) using a Deep Residual Network (ResNet) model by addressing the issue of convolutional layers in conventional Convolutional Neural Networks (CNN) and applying image preprocessing techniques.

Methods: The proposed method involves using Contrast Limited Adaptive Histogram Equalizer (CLAHE) and Boosted Anisotropic Diffusion Filters (BADF) for equalization and noise removal and K-means clustering for segmentation. A ResNet-50 model with shortcut links between three residual layers is proposed to extract features more efficiently.

A Rare Finding of Pancreatic Involvement in a Case of Burkitt's Lymphoma.

Burkitt's lymphoma (BL) is a highly aggressive type of B-cell non-Hodgkin lymphoma. BL commonly occurs in children of age 4-7 years and is uncommon in adults, with a worse prognosis. Patients often present with a rapidly growing mass typically involving the abdomen (liver and spleen) and head and neck (nodes, jaw, and facial bones).

Evaluation of the Role of BIOCHIP Mosaic Based Indirect Immunofluorescence and ELISA BP 180 and BP 230 Autoantibodies in the Diagnosis of Bullous Pemphigoid Patients.

Background: Bullous pemphigoid (BP) is characterized by tissue-bound and circulating Immunoglobulin G (IgG) autoantibodies against BP 180 and BP 230. Diagnosis of BP is a multi-step procedure. Enzyme-linked immunosorbent assay (ELISA) is a quantitative analysis of target antigens, whereas BIOCHIP mosaic-based indirect immunofluorescence (IIF) has a combination of screening and target antigen-specific substrates in a single miniature incubation field.

SubmitoLoc: Identification of mitochondrial sub cellular locations of proteins using support vector machine.

Mitochondria are important sub-cellular organelles in eukaryotes. Defects in mitochondrial system lead to a variety of disease. Therefore, detailed knowledge of mitochondrial proteome is vital to understand mitochondrial system and their function.

Benign lymphoepithelial lesion of the minor salivary gland - A rare presentation as a palatal swelling.

Benign lymphoepithelial lesion (BLEL) is characterized by extensive lymphocytic infiltration of the major salivary glands and may be associated with Sjogren's syndrome or HIV infection. The involvement of the palatal minor salivary glands is extremely rare. We report an isolated case of BLEL affecting the palatal minor salivary glands, presenting as a palatal swelling in a 37-year-old female patient.

Detection of estrous biomarkers in the body exudates of Kangayam cattle (Bos indicus) from interplay of hormones and behavioral expressions.

Behavioral expressions and biochemical composition of body exudates are significantly altered in concert with the endocrine status, which are all clear indicators of physiological conditions of animals. In this study, we sought to infer about the reproductive physiological status of Kangayam cattle (Bos indicus) by analyzing behaviors, endocrine pattern, and body exudates and further to discover estrous biomarkers so as to facilitate timely artificial insemination/mating and to aid in aspects of conservation of the species. Therefore, in this study, we followed Kangayam cows through pre-estrous to post-estrous phases to correlate the endocrine dependence of biochemical constituents in urine and cervical mucus and sought to identify estrous biomarkers.

Nglyc: A Random Forest Method for Prediction of N-Glycosylation Sites in Eukaryotic Protein Sequence.

Background: N-Glycosylation is one of the most important post-translational mechanisms in eukaryotes. N-glycosylation predominantly occurs in N-X-[S/T] sequon where X is any amino acid other than proline. However, not all N-X-[S/T] sequons in proteins are glycosylated.

Identification of potential pheromone source in sows.

Pheromones play a pivotal role in intra-species communication for reproduction and social behavior in a variety of mammals, such as boars. For boars, saliva is a rich source of pheromones, however, the identification of additional sources and relative abundance of pheromones in various body fluids of sows is also essential to understand the reproductive behaviors of pigs. The present study was designed to identify the source(s) of pheromones in sows.

A ten year study of prevalence, antimicrobial susceptibility pattern, and genotypic characterization of Methicillin resistant Staphylococcus aureus causing ocular infections in a tertiary eye care hospital in South India.

Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of vision threatening ocular infections. This study aimed to determine the prevalence and antimicrobial susceptibility pattern of MRSA and their genotypic characterization in ocular infections. The study period was from January 2007 to December 2017 in Aravind Eye Hospital, Madurai.

Shape memory alloy reinforced 5 mm ultra-thin rigid link surgical instrument with force-feedback.

We report the development of a rigid link surgical instrument for surgical robotics. The device is only 5 mm in diameter and equipped with a shape memory alloy for better gripping, which avoids the use of mechanical gears. This ultra-thin instrument has a unique force sensor mount at the gripper to capture forces as low as 288 mN from the surgical site.

Utilization of Industrial Waste for the Production of Bio-Preservative from Bacillus licheniformis Me1 and Its Application in Milk and Milk-Based Food Products.

The bio-preservative efficacy of a partially purified antibacterial peptide (ppABP) produced by Bacillus licheniformis Me1 in an economical medium developed using agro-industry waste was evaluated by direct application in milk and milk-based food products. The addition of ppABP in milk samples stored at 4 ± 2 °C and 28 ± 2 °C resulted in the growth inhibition of pathogens Listeria monocytogenes Scott A, Micrococcus luteus ATCC 9341, and Staphylococcus aureus FRI 722. The shelf life of milk samples with added ppABP increased to 4 days at 28 ± 2 °C, whereas curdling and off-odor were noticed in samples without ppABP.

Impact of Si4+ Ions Doping on the Electrochemical Cycling Performance of NiTiO3 as Anodes for Li-Lon Batteries.

Pristine and Si4+ doped NiTiO3 are successfully synthesized by molten salt method and electrochemically characterized for its use as an anode material for Li-ion batteries. The X-ray diffraction (XRD) results enumerates that the lattice parameter and the cell volume decreases upon the addition of Si4+ due to its smaller ionic radius. The presence of Si4+ in NiTiO3 structure was also confirmed using FTIR analysis, which showed the stretching vibrations of Si-O at -1008 cm(-1).

Effect of pH on the sonochemical synthesis of BiPO4 nanostructures and its electrochemical properties for pseudocapacitors.

Using sonochemical method, BiPO4 nanocrystals were prepared at different pH conditions (pH-1, 3, 5, 7, 9 & 12) for the possible applications of pseudocapacitor electrodes. The prepared BiPO4 nanocrystals belong to monoclinic structure with P21 space group. The SEM image revealed that the particles changed from irregular coarse shape into rod like structure (pH-1 to 7) which finally collapsed into irregular aggregates (pH-9 to pH-12).

The effect of matrix stiffness of injectable hydrogels on the preservation of cardiac function after a heart attack.

This study compares the effect of four injectable hydrogels with different mechanical properties on the post-myocardial infarction left ventricle (LV) remodeling process. The bioactive hydrogels were synthesized from Tetronic-fibrinogen (TF) and PEG-fibrinogen (PF) conjugates; each hydrogel was supplemented with two levels of additional cross-linker to increase the matrix stiffness as measured by the shear storage modulus (G'). Infarcts created by ligating the left anterior descending coronary artery in a rodent model were treated with the hydrogels, and all four treatment groups showed an increase in wall thickness, arterial density, and viable cardiac tissue in the peri-infarct areas of the LV.

Enhanced infarct stabilization and neovascularization mediated by VEGF-loaded PEGylated fibrinogen hydrogel in a rodent myocardial infarction model.

Most tissue engineering therapies require biomaterials that are able to induce an angiogenic response to support tissue regeneration. In addition angiogenic growth factor signaling plays an essential role in controlling the process of angiogenesis and matrices have the potential of regulating the concentration of growth factors within the cellular microenvironment. Here we demonstrated myocardial protection and improved post-infarct vascularization of the infarcted hearts using a biosynthetic injectable hydrogel consisting of polyethylene glycol and fibrinogen (PEG-fibrinogen) loaded with vascular endothelial growth factor-A (VEGF-A).

Novel whole-cell Reporter Assay for Stress-Based Classification of Antibacterial Compounds Produced by Locally Isolated Bacillus spp.

Reporter bacteria are beneficial for the rapid and sensitive screening of cultures producing peptide antibiotics, which can be an addition or alternative to the established antibiotics. This study was carried out to validate the usability of specific reporter strains for the target mediated identification of antibiotics produced by native Bacillus spp. isolated from different food sources.

Development and application of active films for food packaging using antibacterial peptide of Bacillus licheniformis Me1.

Aims: An attempt was made to evaluate the effectiveness of partially purified antibacterial peptide (ppABP) produced by Bacillus licheniformis Me1 for food preservation by means of active packaging.

Methods And Results: The active packaging films containing ppABP were developed using two different packing materials [low-density polyethylene (LDPE) and cellulose films] by two different methods: soaking and spread coating. The activated films showed antibacterial activity against pathogens.

Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats.

Objective: To investigate the wound-healing potency of the ethanolic extract of the flowers of Hibiscus rosa sinensis.

Materials And Methods: The wound-healing activity of H. rosa sinensis (5 and 10% w/w) on Wistar albino rats was studied using three different models viz.

Antibacterial Peptides, Probiotic Properties and Biopreservative Efficacy of Native Bacillus Species Isolated from Different Food Sources.

In this study, we evaluated the occurrence of antibacterial peptide (ABP)-producing Bacillus spp. in fermented foods. Among 78 isolated cultures, 25 potential ABP-producing stains were selected and differentiated genotypically and phenotypically.

Safety assessment of Bacillus licheniformis Me1 isolated from milk for probiotic application.

In this study, an in vivo toxicological safety assessment of Bacillus licheniformis Me1, a native isolate from milk, was performed. An acute toxicity study in male albino Wistar rats demonstrated no treatment-related illness or mortality. A 90-day subchronic oral toxicity study using 2 doses (1.