Methylation Status of IGF-Axis Genes in the Placenta of South Indian Neonates with Appropriate and Small for Gestational Age.

Objective: Altered methylation patterns of insulin-like growth factor (IGF)-axis genes in small for gestational age (SGA) have been reported in different populations. In the present study, we analyzed the methylation status of IGF-axis genes in the placenta of appropriate for gestational age (AGA) and SGA neonates of South Indian women.

Methods: Placental samples were collected from AGA ( = 40) and SAG ( = 40) neonates.

The Role of Insulin-like Growth Factor-Axis and Mitotic Index in South Indian Neonates with Small for Gestational Age.

Objective: IGF-axis and mitotic capacity of cells play a vital role in fetal growth. We compared IGF1, IGF2, and IGFBP3 protein levels, mitotic indices, and mRNA expression in appropriate for gestational age (AGA) and small for gestational age (SGA) neonates of Indian women.

Methods: Cord blood ( = 80) and placental samples ( = 40) were collected from AGA and SGA neonates.