Publications by authors named "Nithikan Suthumchai"
Drug reactions with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are severe cutaneous adverse hypersensitivity reactions with distinct clinical manifestations. Regulatory T (Treg) cells may behave differently in these syndromes, contributing to their diverse clinical features and outcomes. This study compared Treg dynamics between DRESS and SJS/TEN patients during the acute and recovery phases.
View Article and Find Full Text PDFExosomal microRNAs from PBMCs stimulated with culprit drugs enhanced keratinocyte cell death in Stevens-Johnson syndrome/toxic epidermal necrolysis.
J Eur Acad Dermatol Venereol
July 2023
Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reactions with eosinophilia and systemic symptoms (DRESS) are both severe cutaneous adverse reactions. Keratinocyte death is much more prominent in SJS/TEN compared to DRESS.
Objective: This study aimed to investigate the role of exosomal miRNAs on keratinocyte death in SJS/TEN.
Article Synopsis
- The study investigated the effectiveness of HLA-B allele prescreening and drug-specific IFN-γ-releasing cells in preventing and identifying the drugs responsible for severe cutaneous adverse reactions (SCARs) in patients.
- It involved 160 patients from Thai universities, revealing that common culprits included anticonvulsants, allopurinol, and beta-lactams, with prescreening having the potential to prevent 21.2% of cases.
- The findings indicated that drug-specific IFN-γ-releasing cells were detectable in about 45.7% of SCAR patients, suggesting a need for improved strategies to better prevent and identify culprit drugs.