Immunogenicity of mRNA-1273 and BNT162b2 in Immunocompromised Patients: Systematic Review and Meta-analysis Using GRADE.

Introduction: Immunocompromised (IC) patients mount poor immune responses to vaccination. Higher-dose coronavirus disease 2019 (COVID-19) vaccines may offer increased immunogenicity.

Methods: A pairwise meta-analysis of 98 studies reporting comparisons of mRNA-1273 (50 or 100 mcg/dose) and BNT162b2 (30 mcg/dose) in IC adults was performed.

Estimation of parameter of fractional order COVID-19 SIQR epidemic model.

Epidemic model have been broadly used in different forms for studying and forecasting epidemiological processes the spread of dengue, zika virus , HIV, SARS and recently , the 2019-20 corona virus which is an ongoing pandemic of corona virus disease (COVID-19). In the present paper, an inverse problem to find the parameters for the single term (multi term) fractional order system of an outbreak of COVID-19 is considered. In the starting, we propose a numerical method for fractional order corona virus system based on the Gorenflo-Mainardi-Moretti-Paradisi (GMMP) scheme, and then to find the parameters we use GMMP method and the modified hybrid Nelder-Mead Simplex search and particle swarm optimization algorithm.

The Metabolomic Strategy in Tuberculosis Therapy.

Tuberculosis causes around 1.4 million deaths every year remaining to be a major cause of morbidity and mortality. Mycobacterium tuberculosis is adept at surviving the assault of our immune system, which has perplexed many researchers.